About STRIM
Strategy for the development of scientific research in the field of cancer immunotherapy STRIM
The project was launched on September 1, 2025 at IMDiK under the supervision of Magdalena Winiarska, PhD.
The main goal is to improve the development of immunotherapy that will ultimately benefit cancer patients.
Necessary factors to achievie this goal:
Establishing long-term and stable collaborations
with foreign scientists developing new CAR-T treatments through partnerships with two European centers:
The result of the cooperation will be the improvement of scientists' competences thanks to the exchange of knowledge and experience during study visits to Partners, which will be another step towards the development of new methods of cancer immunotherapy.
You can follow the progress of this task here:
- Marta Krawczyk - Oviedo
Education of young, competent scientific staff thanks 
to financing from funds allocated by NAWA for participation in conferences, workshops and trainings
Investing in the scientific development of young researchers will not only ensure that their competences are improved, which will be used in research on new ways to fight cancer, but will also instill in them the passion necessary to overcome the inevitable difficulties in scientific work.
How young scientists are educated thanks to the NAWA program: students and doctoral students working at MMRI PAS can be observed here:
- research trip to Geneva
Continuous training of scientific staff (especially young scientists) through active participation in scientific meetings organised at Mossakowski Medical Research Institute, including presentations of own research results and critical discussions of publications from leading scientific journals.
The list of speakers and their topics is available here: OPEN
You can follow the progress of this task here:
- Mikołaj Jacyno, a beginner PhD student at the Department of Immunology at MMRI PAS, expanded his knowledge of modern immunotherapy methods thanks to his participation in the virtual conference entitled "Next Generation Immunotherapies: From Innovative Approaches to Overcoming Resistance and Beyond".
The STRIM project also envisages the participation of young scientists from MMRI PAS in international scientific conferences ensuring contact with the latest achievements in cancer immunotherapies.
Continuing education of experienced scientific straff through participation in scientific conferences and professional trainings in project management, human potential and scientific cooperation.
Marta Krawczyk in Oviedo
MARTA KRAWCZYK - STUDY TRIP
to the University of Oviedo (laboratory of Prof. Xose S. Puente)
Term
16.11.2025 – 13.12.2025
Purpose of the visit
Rozwój międzynarodowej współpracy naukowej ze strategicznymi zagranicznymi ośrodkami naukowymi, zdobycie umiejetności z zakresu analiz genetycznych, badania zmian epigenetycznych i bioinformatyki.Development of international scientific cooperation with strategic foreign research centers, acquisition of skills in the field of genetic analysis, research on epigenetic changes and bioinformatics.
Course of the visit
during the visit, two research taks were completed:
- Optimizstion and preparation of ATACseq (Assay for Transposase-Accessible Chromatin with high-throughput sequencing) libraries using cellular models - in close collaboration with Dr. Javier Fernández-Mateos.
- Study of the evolution of mutations in the CD19 gene and identification of mutations in the CD19 gene promoter in model cell lines - under the supervision of Dr. Ana Gutiérrez-Fernández.
Acquired skills & continued collaboration
During the study visit, Marta acquired skills in preparing ATACseq sequencing libraries, assessing their quality, and pooling them for sequencing, as well as conducting experiments and analyzing mutation testing results using the Sanger sequencing method.
The ATACseq sequencing results will be analyzed in collaboration with Prof. Xose S. Puente's team and will be the subject of further collaboration or a joint manuscript.
The results regarding the analysis of mutation evolution in the CD19 gene will be incorporated into a manuscript on the phenomenon of resistance to anti-CD19 CAR-T therapy using different CAR structures, which is currently in the submission process.
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List Otwarty Inicjatywy Obywatelskiej Instytutów PAN
Szanowni Państwo,
przedstawiamy List Otwarty Inicjatywy Obywatelskiej Instytutów PAN w sprawie propozycji Komitetu Polityki Naukowej MNiSW z 30 kwietnia 2020 r. dotyczący reformy Polskiej Akademii Nauk.
Zamieszczamy tekst listu (pdf) oraz link do strony gdzie zainteresowani będą mogli złożyć swoje podpisy.
z poważaniem,
Dyrekcja IMDIK
OLIGOPHAGY: Polish-Swiss WEAVE-UNISONO project
OLIGOPHAGY: Investigating the role of autophagy in oligodendrocytes in hypoxic-ischemic
perinatal brain injuries (2021/03/Y/NZ4/00214, (2022-2025), NCN WEAVE UNISONO - project in Polish-Swiss cooperation),
PI: prof. Joanna Sypecka
AIM OF THE PROJECT
Autophagy is a physiological mechanism based on degrading and recycling selected cellular biomolecules and organelles due to forming a multimembrane intermediate compartment. As one of the major mechanisms involved in maintaining tissue homeostasis in response to various forms of stress, autophagy is believed to be modulated by a temporary limitation of glucose and oxygen supply, evoked by an episode of perinatal asphyxia. In fact, intracellular pathways and the intensity of this process are thought to be one of the major mechanisms involved in the initiation of either physiological neuroregeneration or development of neurodegenerative disorders, associated with poor neurodevelopmental outcomes in the survived babies. Therefore the modulation of the autophagy process could be a novel innovative strategy in providing neuroprotection and promoting natural, endogenous reparative processes. However, studies on process of autophagy in oligodendroglial cells are still scarce and to date moderate hypothermia is the only available clinical intervention after perinatal asphyxia. Moreover, as revealed by the latest clinical data, hypothermia actually neither provides complete brain protection nor efficiently stimulates endogenous neuroreparative processes. New treatment options are therefore urgently needed to protect fragile developing brains from the fatal consequences of HI damage and to restore proper physiological functioning of the injured nervous tissue. To address this issue, the main aim of the study is to describe way(s) in which oligodendroglial autophagy proceeds and to fill in the gaps in the knowledge concerning mechanisms of the oligodendrocyte involvement in the development of fatal consequences of perinatal, asphyxic injury.
With aim of comprehensively evaluating autophagy processes in oligodendrocyte differentiation and functioning within the nervous tissue, six different working model systems will be used in joint research project of experts from Polish and Swiss laboratories. The intracellular pathways of signal transduction, potentially engaged in oligodendroglial autophagy, will be studied by means of the advanced methods of molecular biology.
PROJECT TEAM
- NeuroRepair Department MMRI PAS:
- Joanna Sypecka - https://orcid.org/0000-0003-1647-7711
- Małgorzata Ziemka Nałęcz - https://orcid.org/0000-0001-8412-995X
- Justyna Janowska - https://orcid.org/0000-0003-0093-8173
- Justyna Gargaś - https://orcid.org/0000-0002-4491-7633
- Paulina Gębala, PhD sandidate*
- Michał Frańczak, PhD candidate*
* Doctoral School of Translational Medicine with the profile: ‘Diagnostics, modelling and treatment of human diseases from gene to clinic’. : ‘Bench to Bedside - B 2 B 4 PhD’
- Department of Fundamental Neurosciences, Faculty of Biology and Medicine, University of Lausanne;
- Clinic of Neonatology, Department of Women, Mother and Child, University Hospital Center of Vaud, Lausanne, Switzerland: Julien Puyal, Pauline Depierre , Vanessa Ginet, Anita C. Truttmann
NEW EQUIPMENT FOR CELL CULTURE LABORATORY:
Hypoxylab - hypoxia workstation that provides a HEPA-filtered environment in which oxygen, carbon dioxide, temperature and humidity are precisely controlled.
EXPERIMENTAL MODELS AND RESEARCH TECHNIQUES:
- in vitro: primary cultures of neonatal glial cells: oligodendrocytes, astrocytes and microgliai
Źródło grafiki: https://link.springer.com/article/10.1007/s10571-023-01380-2 - ex vivo: organotypic hippocampal slices, coronal brain slices
- in vivo: hipoxia-ischemia model on neonatal rats
- OGD: oxygen and glucose deprivation to mimic hypoxia-ischemia in vitro/ex vivo
Źródło grafiki: https://onlinelibrary.wiley.com/doi/10.1111/bpa.13255
SELECTED RESULTS OF THE PROJECT IMPLEMENTATION
- demonstration of changes in the white matter of the rat brain after HI by MRI, immunofluorescence staining and transmission microscopy,
- identification of oligodendrocyte differentiation disorders as the cause of the observed changes,
References:
Janowska J, Gargas J, Zajdel K, Wieteska M, Lipinski K, Ziemka-Nalecz M, Frontczak-Baniewicz M, Sypecka J. Oligodendrocyte progenitor cells' fate after neonatal asphyxia-Puzzling implications for the development of hypoxic-ischemic encephalopathy. Brain Pathol. 2024 Mar 19:e13255. doi: 10.1111/bpa.13255.
JOINT SCIENTIFIC VENTURES:
Organization of scientific sessions:
- Recent advances in therapeutic strategies for neurodevelopmental diseases –during The XVIth International Symposium Molecular Basis of Pathology and Therapy in Neurological Disorders (17 – 18 October 2024, Warsaw, Poland) https://ncs2024.imdik.pan.pl/?id=3)
- „Decifering role of autophagy in neurological diseases” - during XV International Symposium Molecular Basis of Pathology and Therapy in Neurological Disorders, (20-22.10.2022, Warszawa) https://ncs2022.imdik.pan.pl/?id=3
Narodowe Centrum Nauki ogłosiło wyniki konkursów
Miło nam poinformować o nowych projektach zakwalifikowanych do finansowania przez Narodowe Centrum Nauki.
