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Hepentrans - General informations

General information

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The project entitled “CONTRIBUTION OF GLUTAMINE TRANSPORT TO BRAIN EDEMA AND DYSFUNCTION OF THE GLUTAMATERGIC SYNAPSE ASSOCIATED WITH HEPATIC ENCEPHALOPATHY” is founded by The National Centre for Research and Development in the frame of the Polish-Norwegian Scientific Collaboration Program “CORE”

 

The Principal Investigator of the Project is Prof. Jan Albrecht, Head of Department of Neurotoxicology, Mossakowski Medical Research Centre Polish Academy of Sciences.

 

The Norwegian partners are: Prof. Farrukh A. Chaudhry from The Biotechnology Centre of Oslo & Centre for Molecular Biology and Neuroscience, University of Oslo and Prof. Ursula Sonnewald, Head of Department of Neuroscience, Norwegian University of Science and Technology in Trondheim. The 3-year grant amounts to  ~850000 EUR.

The project addresses disturbances in expression/function of glutamine transporter, SN1 - an unexplored aspect of the pathogenesis of hepatic encephalopathy (HE).

The project is expected to provide a thorough analysis of the role of changes in the glutamine-glutamate metabolic cycle in the pathogenesis of HE.

It focuses on the hypothesis that inhibition of SN1 transporter -mediated efflux of newly synthesized Gln from astrocytes is the step that links glutamine-glutamate cycle impairment to both the astrocytic (brain edema) and neuronal (glutamatergic dysfunction) manifestations of HE.

Apart from the unraveling a pathogenetic aspect of HE, the employment - for the first time - of the SN1 knock-out (KO) mice and in vitro cell culture models with silenced SN1 should allow an exhaustive verification of the involvement of SN1 in channeling Gln towards the glutamatergic synapse and of its impact on the glutamatergic transmission in healthy brain.