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Summary of project results

The project was indispensable for bringing  together groups of specialists in complementary fields of neurobiology, to tackle a critical aspect of the pathomechanism of acute hepatic encephalopathy, a complex neurological disorder which is a worldwide socioeconomic burden.  The project was not intended to, so it fell short of providing consumable output (treatment modalities). However, the project largely extended our knowledge on the role of impairment of a biochemical process  in the brain (glutamine transport) that links the two  interrelated, potentially lethal  symptoms of the disease: brain oedema and hepatic coma. Apart from the gain in knowledge, the project provided significant methodological enrichment and improvement of  research facilities of the Polish partner,   allowed to extend active interest in the topic to other research groups which joined the project in its course, and set stage for future collaboration between the partners in Warsaw and in Oslo. It is hoped that the achieved progress in unravelling the mechanism of acute hepatic encephalopathy will in the future be translated to treatment. 




Program of the 2nd “HEPENTRANS”  Conference to be held in Hilton Garden Inn Kraków, May 22, 2014 

Chair: Jan Albrecht, Farrukh Chaudhry


  1. Characteristics of the AOM model in wild-type mice – presentation by Magdalena Zielińska

  2. Preliminary electrophysiological characterization of  frog oocytes injected with  SN1 mRNA treated with ammonia/glutamine – presentation by Farrukh Chaudhry,  followed by panel discussion

  3. Characteristics of metabolic fates of [2-13C] acetate and [1,6-13C] glucose wild mouse astrocytes in cultures, following short-term and long-term treatment with ammonia presentation by Ursula Sonnewald followed by panel discussion

  4. Discussion on formal issues (money flow,  task execution status, progress with formalities regarding access to KO mice).

  5. WP’s schedule-recapitulation and discussion (updating of the charts, deadlines for tasks and reporting).


The conference has no tied-up time schedule, but its duration should not exceed 1.5 h





MMRC invites applicants for PhD study that will be realized in Neurotoxicology Department, in the frame of the project titled: „CONTRIBUTION OF GLUTAMINE TRANSPORT TO BRAIN EDEMA AND DYSFUNCTION OF THE GLUTAMATERGIC SYNAPSE ASSOCIATED WITH HEPATIC ENCEPHALOPATHY.”

This National Center for Research and Development (NCRC)-funded position is available for a period of up to 4 years (starting Oct. 2013), and requires previous experience in basic biochemistry and cell biology. Experience with neurobiology and microscopy techniques will be an additional asset.

•          Fellowship: 2200 PLN/month (550 Euro/month)

To apply, please send your motivation letter, CV and contact to at least one referee.

Candidate should hold a Master of Science degree (or equivalent) obtained not later than October 1, 2013. Deadline for application submission: September 31st, 2013.

For additional information please contact: This email address is being protected from spambots. You need JavaScript enabled to view it.