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Species-specific models in toxicology: in vitro epithelial barriers.

Environ Toxicol Pharmacol. 2019 Aug;70:103203. doi: 10.1016/j.etap.2019.103203. Epub 2019 Jun 1.
Bertero A1, Augustyniak J2, Buzanska L2, Caloni F3.
Author information
1 Università degli Studi di Milano, Department of Veterinary Medicine (DIMEVET) Milan, Italy.
2 Stem Cell Bioengineering Unit, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland.
3 Università degli Studi di Milano, Department of Veterinary Medicine (DIMEVET) Milan, Italy. Electronic address: This email address is being protected from spambots. You need JavaScript enabled to view it..
Abstract
Species-specific in vitro epithelial barriers represent interesting predictive tools for risk assessment evaluation in toxicological studies. Moreover, these models could be applied either as stand-alone methods for the study of absorption, bioavailability, excretion, transport, effects of xenobiotics, or through an Integrated Testing Strategy. The aim of this review is to give a comprehensive overview of in vitro species-specific epithelial barrier models from bovine, dog and swine. Bovine mammary epithelial barrier as a fundamental instrument for the evaluation of the toxicant excretion, the blood brain barrier as a useful first approach in toxicological and pharmacological studies, the porcine intestinal barrier, the canine skin barrier, and finally the pulmonary barrier from bovine and swine species are described in this review.
Copyright © 2019 Elsevier B.V. All rights reserved.
KEYWORDS:
Barriers; Species-specific; Toxicology; in vitro

Species-specific models in toxicology: in vitro epithelial barriers.

Environ Toxicol Pharmacol. 2019 Aug;70:103203. doi: 10.1016/j.etap.2019.103203. Epub 2019 Jun 1.

Bertero A1, Augustyniak J2, Buzanska L2, Caloni F3.

Author information

1        Università degli Studi di Milano, Department of Veterinary Medicine (DIMEVET) Milan, Italy.

2        Stem Cell Bioengineering Unit, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland.

3        Università degli Studi di Milano, Department of Veterinary Medicine (DIMEVET) Milan, Italy. Electronic address: This email address is being protected from spambots. You need JavaScript enabled to view it..

Abstract

Species-specific in vitro epithelial barriers represent interesting predictive tools for risk assessment evaluation in toxicological studies. Moreover, these models could be applied either as stand-alone methods for the study of absorption, bioavailability, excretion, transport, effects of xenobiotics, or through an Integrated Testing Strategy. The aim of this review is to give a comprehensive overview of in vitro species-specific epithelial barrier models from bovine, dog and swine. Bovine mammary epithelial barrier as a fundamental instrument for the evaluation of the toxicant excretion, the blood brain barrier as a useful first approach in toxicological and pharmacological studies, the porcine intestinal barrier, the canine skin barrier, and finally the pulmonary barrier from bovine and swine species are described in this review.

KEYWORDS:

Barriers; Species-specific; Toxicology; in vitro

 

Additional information