DNA - index in tumor tissue as a predictive factor for pancreatic cancer biology.


Project proposed under the KNOW PhD studies in MMRC

"DNA - index in tumor tissue as a predictive factor for pancreatic cancer biology."

Supervisor: Marek Durlik, MD, PhD, Assoc. Prof.

Department of Surgical Research and Transplantology

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Pancreatic cancer is the seventh and the eighth leading cause of death from cancer, respectively in men and women. Pancreatic cancer has still extremely poor prognosis. Surgery is the only approved treatment, but resection rate remains below 20%. Early identification of the patients with aggressive metastatic tumor biology is important for personalized treatment planning. Histopathological parameters tumor size (pT)  and lymph node status (pN) have little impact on postoperative adjuvant therapy. DNA index score of the tumor seems to be a strong predictor in the assessment of tumor biology and may be helpful in selected high-risk patients and introduce individualized  multidisciplinary treatment strategy.

 

The candidate should first contact the Supervisor to complete the application procedure.