Contribution of vascular changes to sodium-dependent hypertension.

 

Project proposed under the KNOW PhD studies in MMRC

"Contribution of  vascular changes to sodium-dependent hypertension."

Supervisor: Ewa Koźniewska-Kołodziejska, PhD, Assoc. Prof. / Krzysztof H. Olszyński, PhD

Department of Neurosurgery

Contact: Ten adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript.; Ten adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript.; 22 60 86 489

 

Increase of plasma sodium concentration is a well known risk factor for arterial hypertension. Numerous experimental data have shown that local renin-angiotensin-aldosterone systems (RAAS) are upregulated in sodium-dependent hypertension (SDH). Our hypothesis is that upregulation of vascular RAAS participates in structural and functional changes of blood vessels which results in the increase of their resistance. Therefore, the goal of the study is to assess the effectivenss of antihypertensive therapy with angiotensin converting enzyme (ACE) inhibitors (systemic RAAS) and non-ACE inhibitors (tissue RAAS) in preventing changes of resistance blood vessels morphology and function. Rats with unilateral nephrectomy fed high sodium diet will be used as a model of SDH. Endothelial functions and reactivity to vasoconstrictors of resistance vessels isolated from the animals with established SDH will be studied in the organ chamber. Moreover, morphology of these vessels with particular emphasis on endothelium will be examined.

 

The candidate should first contact the Supervisor to complete the application procedure.