The role of ANGPTLs in regulation of lipid metabolism during prolonged exercise performed after different types of diet.


Project proposed under the KNOW PhD studies in MMRC

"The role of ANGPTLs in regulation of lipid metabolism during prolonged exercise performed after different types of diet."

Supervisor: Andrzej Ziemba, PhD, Assoc. Prof.

Department of Applied Physiology

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Over the last decade angiopoietin- like proteins (ANGPTLs) emerge as important players in many aspects of energy metabolism including regulation of food intake, glucose homeostasis and energy expenditure. Specifically they may act as potent regulators of lipid metabolism by inhibition of lipoprotein lipase and stimulation adipose tissue lipolysis. Surprisingly, in available literature the studies concerning ANGPTL impact on physical exercise metabolism are limited. During prolonged physical effort free fatty acids are major source of energy for working muscles. The aim of the study will be assessment of ANGPTL role in lipid and carbohydrate metabolism during prolonged physical effort in humans. Since during exhausting effort the type of energy source is important and depends from type of previous energy load, the studies will be performed after carbohydrate or fat rich meal.


The candidate should first contact the Supervisor to complete the application procedure.