RESEARCH PROJECTS AT MMRI PAS PROJECTED FOR THE YEAR 2022
| Project number |
Research project title |
Project Manager |
| 1 | Vascular and metabolic mechanisms of cerebral ischemia in patients and in experimental models of ischemic and cerebral haemorrhagic stroke. |
Prof. Ewa Koźniewska-Kołodziejska MD, PhD |
| 2 | Clinical and pathogenetic studies in non-Alzheimer’s dementia, Alzheimer’s disease, amyotrophic lateral sclerosis and Tourette's syndrome. |
Prof. Cezary Żekanowski MD, PhD |
| 3 | The search for common pathogens in cerebral ischemia and Alzheimer's disease. |
Prof. Ryszard Pluta MD, PhD |
| 4 | Phenotypic and genotypic studies in neoplastic and ischemic processes in the central nervous system. | Prof. Ewa Matyja MD, PhD Department of Experimental and Clinical Neuropathology |
| 5 |
Analysis of molecular mechanisms of cytoskeletal disorders in CNS neurons in animal models of neuropsychiatric disorders: the role of mTOR kinase. |
Prof. Agata Adamczyk MD, PhD |
| 6 |
The search for new euro-repair strategies: evaluation of the role of exo- and endogenous factors in intercellular interactions in normal and in selected pathophysiological conditions of the CNS. |
Joanna Sypecka MD, PhD, MMRI Prof. Department of Restorative Neurobiology |
| 7 | The role of bioactive sphingolipids and NAD-dependent enzymes in the processes of neurodegeneration/ neuroprotection. |
Prof. Robert Strosznajder MD, PhD Laboratory of Preclinical Research of Neuroprotective and Environmental Agents |
| 8 | The role of natural adaptive processes and exo- and endogenous substances of neuroprotective potential in prevention and therapy of neurodegenerative disorders. | Prof. Elżbieta Salińska MD, PhD Laboratory of Pharmacology and Neurochemistry |
| 9 | Intercellular interactions and their role in damage mechanism in models of tauopathy and autoimmune encephalomyelitis. | Prof. Lidia Strużyńska MD, PhD; Laboratory of Pathological Neurochemistry |
| 10 | The search for mechanisms of varied neuronal sensitivity to ischemic episode: differences in mitochondrial metabolism and mitochondria dynamics. |
Prof. Barbara Zabłocka MD, PhD |
| 11 | Assessment of clinical progression and phenotypic spectrum of motor polyneuropathy caused by p.Thr151Ile mutation in Hsp27/HSPB1 gene. |
Prof. Andrzej Kochański MD PhD; |
| 12 | The study of the impact of in vitro microenvironment on production and development of brain organoids from human induced pluripotent stem cells. |
Prof. Leonora Bużańska MD, PhD |
| 13 | Identification of factors which accompany the hyperammonaemia episode in patients with inherited deficits of urea cycle enzymes and selected metabolic diseases. |
Prof. Magdalena Zielińska MD, PhD |
| 14 |
Search for common metabolic pathways in ageing and obesity: analysis of the relationship of polymorphisms of the gene encoding the receptor of advanced glycation end products (AGE) with the development of obesity in various age groups. |
Alina Kuryłowicz, MD, PHD MMRI prof. Clinical and Research Department of Human Epigenetics |
| 15 | Biological effects of intraventricular administration of streptozotocin in a rat metabolic model of Alzheimer's disease (AD). |
Prof. Paweł Grieb MD, PhD Department of Experimental Pharmacology |
| 16 |
|
Piotr Lipiński MD, PhD Department of Neuropeptides |
| 17 | The role of ATGL in the regulation of SIRT1 activity and biogenesis of podocytic mitochondria in hyperglycaemia | Agnieszka Piwkowska MD, PhD, MMRI prof. Laboratory Molecular and Cellular Nephrology |
| 18 | The role of paracrine, metabolic and neuronal factors modifying renal functions in physiological and pathophysiological conditions. |
|
| 19 | Neuroactive arginine derivatives in hippocampus functioning and dysfunction in pathogenesis of selected CNS diseases | Michał Węgrzynowicz MD Laboratory of Basis of Neurodegeneration |
| 20 | Analyses of chemical and neuronal mechanisms of respiration regulation in physiological and pathophysiological conditions. | Katarzyna Kaczyńska MD, PhD, MMRI Prof. Department of Respiration Physiology |
| 21 | Assessment of neurohormonal, haemodynamic, metabolic, immunological and thermoregulatory responses to physiological stimuli and selected pathogens in metabolic and cardiovascular diseases. |
Agnieszka Pawlak MD, PhD, MMRI Prof. Department of Applied Physiology |
| 22 | Development of large-scale molecular modelling methods and their application in the analysis of structure and function of biologically active macromolecules in pathological conditions. | Michał Koliński MD, PhD Bioinformatics Laboratory |
| 23 | The significance of key molecular processes in human neoplasms for neurodegenerative diseases. |
Dawid Walerych MD, PhD |
| 24 | Assessment of ultrastructural changes in cardiac muscle in cardiomyopathy patients. |
Małgorzata Frontczak-Baniewicz MD, PhD |
| 25 | The application of rat ultrasonic vocalizations as a tool for research models of human brain diseases. |
Robert Filipkowski MD, PhD |
| 26 | Assessment of therapeutic abilities of mesenchymal stem cells from Wharton’s jelly isolated, cultured and transported according to the requirements of good manufacturing practice. |
Anna Sarnowska MD, PhD, MMRI Prof. |
| 27 |
Cell transcription - dependent EV protein biomarker platform. |
Agnieszka Bronisz MD, PhD |
| 28 |
|
Jakub Godlewski MD |
| 29 |
Structural and molecular basis of interactions between peptidoglycan hydrolases and bacterial walls. |
Izabela Sabała MD, PhD |
| 30 |
Evaluation of the effectiveness of immunotherapy in tumour immunosuppressive microenvironment. |
Małgorzata Bajor MD, PhD Laboratory of Immunology |
| 31 |
Development of clinical and laboratory diagnostics and a search for new markers in rare diseases and dementia. |
Anna Barczak MD, PhD |
