RESEARCH PROJECTS AT MMRI PAS PROJECTED FOR THE YEAR 2022

Project number

Research project title

Project Manager
Department/Laboratury/Clinical Department

1 Vascular and metabolic mechanisms of cerebral ischemia in patients and in experimental models of ischemic and cerebral haemorrhagic stroke.

Prof. Ewa Koźniewska-Kołodziejska MD, PhD
Laboratory of Experimental and Clinical Neurosurgery

2 Clinical and pathogenetic studies in non-Alzheimer’s dementia, Alzheimer’s disease, amyotrophic lateral sclerosis and Tourette's syndrome.

Prof. Cezary Żekanowski MD, PhD
Clinical and Research Department of Neurodegenerative Diseases CNS

3 The search for common pathogens in cerebral ischemia and Alzheimer's disease.   

Prof. Ryszard Pluta MD, PhD
Laboratory of Ischemic and Neurodegenerative Brain Research MMRI PAS

4 Phenotypic and genotypic studies in neoplastic and ischemic processes in the central nervous system.  
Prof. Ewa Matyja MD, PhD
Department of Experimental and Clinical Neuropathology 

5

Analysis of molecular mechanisms of cytoskeletal disorders in CNS neurons in animal models of neuropsychiatric disorders: the role of mTOR kinase.

Prof. Agata Adamczyk MD, PhD
Department of Cellular Signalling

6

The search for new euro-repair strategies: evaluation of the role of exo- and endogenous factors in intercellular interactions in normal and in selected pathophysiological conditions of the CNS.

 
Joanna Sypecka MD, PhD, MMRI Prof.
Department of Restorative Neurobiology


7
The role of bioactive sphingolipids and NAD-dependent enzymes in the processes of neurodegeneration/ neuroprotection.

Prof. Robert Strosznajder MD, PhD
Laboratory of Preclinical Research of Neuroprotective and Environmental Agents
8 The role of natural adaptive processes and exo- and endogenous substances of neuroprotective potential in prevention and therapy of neurodegenerative disorders.  
Prof. Elżbieta Salińska MD, PhD
Laboratory of Pharmacology and Neurochemistry


9 Intercellular interactions and their role in damage mechanism in models of tauopathy and autoimmune encephalomyelitis.  
Prof. Lidia Strużyńska MD, PhD;
Laboratory of Pathological Neurochemistry
10 The search for mechanisms of varied neuronal sensitivity to ischemic episode: differences in mitochondrial metabolism and mitochondria dynamics.

Prof. Barbara Zabłocka MD, PhD
Molecular Biology Laboratory

11 Assessment of clinical progression and phenotypic spectrum of motor polyneuropathy caused by p.Thr151Ile mutation in Hsp27/HSPB1 gene.

Prof. Andrzej Kochański MD PhD;
Research Department of Neuromuscular Diseases

12  The study of the impact of in vitro microenvironment on production and development of brain organoids from human induced pluripotent stem cells.

Prof. Leonora Bużańska MD, PhD
Department of Stem Cell Bioengineering

13  Identification of factors which accompany the hyperammonaemia episode in patients with inherited deficits of urea cycle enzymes and selected metabolic diseases.

Prof. Magdalena Zielińska MD, PhD
Department of Neurotoxicology

14

Search for common metabolic pathways in ageing and obesity: analysis of the relationship of polymorphisms of the gene encoding the receptor of advanced glycation end products (AGE) with the development of obesity in various age groups.

 
Alina Kuryłowicz, MD, PHD MMRI prof.
Clinical and Research Department of Human Epigenetics
15
Biological effects of intraventricular administration of streptozotocin in a rat metabolic model of Alzheimer's disease (AD).

 
Prof. Paweł Grieb MD, PhD
Department of Experimental Pharmacology
16

 
New GPCR ligands of potential clinical application: synthesis, in vitro, and in vivo studies, molecular modelling.

Piotr Lipiński MD, PhD
Department of Neuropeptides
17 The role of ATGL in the regulation of SIRT1 activity and biogenesis of podocytic mitochondria in hyperglycaemia  
Agnieszka Piwkowska MD, PhD, MMRI prof.
Laboratory Molecular and Cellular Nephrology


18 The role of paracrine, metabolic and neuronal factors modifying renal functions in physiological and pathophysiological conditions.

 
Prof. Elżbieta Kompanowska-Jezierska MD, PhD
Department of Renal and Body Fluid Physiology

19 Neuroactive arginine derivatives in hippocampus functioning and dysfunction in pathogenesis of selected CNS diseases  
Michał Węgrzynowicz MD
Laboratory of Basis of Neurodegeneration


20 Analyses of chemical and neuronal mechanisms of respiration regulation in physiological and pathophysiological conditions.  
Katarzyna Kaczyńska MD, PhD, MMRI Prof.
Department of Respiration Physiology

21
Assessment of neurohormonal, haemodynamic, metabolic, immunological and thermoregulatory responses to physiological stimuli and selected pathogens in metabolic and cardiovascular diseases.

Agnieszka Pawlak MD, PhD, MMRI Prof.
Department of Applied Physiology

22 Development of large-scale molecular modelling methods and their application in the analysis of structure and function of biologically active macromolecules in pathological conditions.  
Michał Koliński MD, PhD
Bioinformatics Laboratory

23 The significance of key molecular processes in human neoplasms for neurodegenerative diseases.

Dawid Walerych MD, PhD
Laboratory of Human Disease Multiomics

24 Assessment of ultrastructural changes in cardiac muscle in cardiomyopathy patients.

Małgorzata Frontczak-Baniewicz MD, PhD
Electron Microscopy Research Laboratory

25 The application of rat ultrasonic vocalizations as a tool for research models of human brain diseases.

Robert Filipkowski MD, PhD
Behaviour and Metabolism Laboratory

26 Assessment of therapeutic abilities of mesenchymal stem cells from Wharton’s jelly isolated, cultured and transported according to the requirements of good manufacturing practice.

Anna Sarnowska MD, PhD, MMRI Prof.
Translational Research Platform in Regenerative Medicine

27

Cell transcription - dependent EV protein biomarker platform.

Agnieszka Bronisz MD, PhD
Tumour Microenvironment Laboratory

28

 
Analysis of the role of cyclic MALAT1 RNA in brain metastasis of breast cancer.


Jakub Godlewski MD
Laboratory of Neurooncology

29

Structural and molecular basis of interactions between peptidoglycan hydrolases and bacterial walls.

Izabela Sabała MD, PhD
Protein Engineering Laboratory

30

Evaluation of the effectiveness of immunotherapy in tumour immunosuppressive microenvironment.


Małgorzata Bajor MD, PhD
Laboratory of Immunology

31

Development of clinical and laboratory diagnostics and a search for new markers in rare diseases and dementia.   

Anna Barczak MD, PhD
Rare Disease Research Platform