Laboratory of Human Disease Multiomics at MMRI PAS is seeking 2 undergraduate students for scientific scholarships in the NCN Opus Project “Oncogene competition - a new interplay mechanism of mutant p53 with CMYC and mutant KRAS in human cancers”.

The stipend is planned for maximum 2 years, starting Jaunary 1st 2025; each stipend - 2500 PLN gross/month. The project is multidisciplinary, biomedical, includes collaborations and will allow to learn and develop skills of open and flexible scientific approach.

Requirements:

• Being a student during of the final 3 years of the full-time M.Sc./M.D. university program in biology, biotechnology, biomedicine, medicine or a similar subject.
• Good command of English and basic practice in scientific writing/presentation of data in English.
• Basic knowledge of molecular biology techniques (e.g. qPCR, RNA handling, western blot etc.) and basic cell culture methods.
• Basic knowledge of handling 3D/organoid cultures.
• Possibility to work on site for a few hours a day on workdays in Warsaw, Poland for the 2 following years.
  
  
  How to apply: Until 20th of December 2024 – please send the CV to dr Dawid Walerych: This email address is being protected from spambots. You need JavaScript enabled to view it.. Do not write a separate motivation letter – if you want to o justify your application, do so briefly in the e-mail in English.

The project: Among the universal driver oncogenes are mutated KRAS, hyperactive CMYC and mutated TP53, last of which upon acquiring missense mutations switches from a tumor suppressor to a potent driver oncogene. It has been shown by our group and in various other studies that these and other oncogenic drivers cooperate and complement one another to promote cell transformation and progression of neoplasias. In the same time it is a paradigm that this cooperation and ability of each driver oncogene to be decisive in oncogenesis is different dependent on the molecular background.

During an ongoing project our group has discovered in cancer cell lines that an important dimension of the molecular background is an “oncogene competition” phenomenon – when one oncogene is taking-over or inhibiting the activity of another oncogene which results in reshaping of molecular programs of both oncogenes.

This phenomenon has never been described before in cancer research and requires a large-scale and mechanism study using normal/cancer cell lines, cancer organoid cultures and in vivo validation in mice.

Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw
is seeking a candidate
for a position of Post-doctoral Research Assistant
or Post-doctoral Research Associate*
* dependent on candidate’s qualifications

Recruitment is related to the project “The mechanisms of mitochondrial damage-dependent neuroinflammation in experimental models of Parkinson’s disease. The role of Parkin dysfunction” OPUS LAP no. 2020/39/I/NZ4/01031 funded by National Science Centre, Poland, carried out in the Department of Cellular Signaling MMRI PAS.

• Scientific discipline: medical sciences
• Announcement date: 19th November 2024
• Application deadline: 15th December 2024
• Link to the website: www.imdik.pan.pl
• Keywords: post-doc, Parkinson’s disease, neurodegeneration, α-synuclein, parkin, mitochondria damage, neuroinflammation.

The area of the research in which the candidate would participate:
Parkin and alpha-synuclein (α-syn) are two key proteins involved in the pathophysiology of Parkinson's disease (PD). This project will characterize the mechanisms by which α-syn–induced parkin dysfunction modulates mitochondrial damage and associated immune response in a pre-clinical murine model of PD based on bilateral injection of oligomeric α-syn into the striatum of C57BL/6J, parkin knock-out (Park2-/-) and parkin overexpressing (PARK2oe) mice. We are seeking a postdoctoral researcher for the project aimed to investigate parkin’s involvement in α-syn–evoked mitochondrial damage, inflammatory response, and neurodegeneration in our murine PD models. Candidate will be involved in investigation of:
1) the time-dependent impact of α-synuclein administration on inflammatory responses and parkin function;
2) the role of parkin in regulating the brain inflammatory response and neurodegeneration after intrastriatal administration of α-synuclein;
3) the effect of parkin overexpression in neuroanatomical and morphological changes evoked by α-synuclein;
4) the effects of pharmacological modulation of mitoflammation on neurodegeneration and behavioral disturbances caused by α-synuclein administration;
Addressing the role of parkin at the crossroads of α-syn spreading and neuroinflammation holds the promise for better understanding of PD pathomechanism and identification of novel therapeutic targets.

 
Description of duties:
• planning and implementation of research tasks in accordance with the schedule of the project,
• designing and conducting experiments with the use of biochemistry, molecular biology and microscopic imaging methods,
• analysis of obtained data,
• presenting the results at the group meetings, external seminars and scientific conferences,
• preparation of scientific publications,
• introducing new research technologies and cooperation with a foreign partner involved in the current research project.

Necessary Requirements:
• PhD degree in biological sciences, neurosciences, pharmacological sciences, medical sciences or relevant,
• experience in laboratory techniques in biochemistry, molecular biology (e.g. DNA, RNA, isolation; Western blot; qPCR; immunohistochemistry; spectrophotometric/fluorometric techniques),
• experience in planning and conducting in vivo procedures (e.g. behavioral analysis),
• working knowledge of statistical software (e.g. GraphPad Prism),
• ability to work in a team and independently,
• excellent knowledge of English, allowing effective communication and preparation of scientific manuscripts,
• indication of Mossakowski Medical Research Institute Polish Academy of Sciences as a first place of employment.

We offer:
• fixed term, full-time employment contract,
• contract period: January 2025 – November 2025,
• the opportunity to work in a pleased atmosphere, in a dynamic, developmental research group,
• scientific collaboration with a research partner in Germany and with other Polish and foreign research institutions,
• opportunity to participate and present obtained results at international conferences.

How to Apply:
Please send your documents to This email address is being protected from spambots. You need JavaScript enabled to view it. indicating the reference number ZKTS-110-1/2024 in your correspondence.

Required documents:
• motivation letter with description of candidate’s scientific interests, scientific work, scientific independency, participation in research grants,
• CV listing candidate’s education, professional experience, scientific achievements, authored or co-authored publications and conference abstracts, internships and training,
• copy of the PhD (or equivalent) diploma,
• references (optionally).

* Depending on candidate’s qualifications, Recruitment Committee may recommend hiring a successful candidate as a Research Assistant or Research Associate.

For more information about the project, please contact prof. dr hab. Agata Adamczyk (This email address is being protected from spambots. You need JavaScript enabled to view it.)

Expected date of the interview: 19th December 2024
Expected decision date: 20th December 2024
Expected job starting date: January 2025

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1. The Controller of your personal data is the Mossakowski Medical Research Institute, Polish Academy of Sciences, A. Pawińskiego 5 St., 02-106 Warsaw, Poland (“MMRI PAS”)
2. The Controller has designated the Data Protection Officer who can be contacted via the following e-mail address: This email address is being protected from spambots. You need JavaScript enabled to view it. or the post address of Controller.
3. Your personal data will be processed for the purpose of carrying out a recruitment process and selecting an employee and concluding a contract for employment at the MMRI PAS.
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