Post-doc to participate in a research project

Announcement date: October 27, 2025
Application deadline: November 27, 2025
Expected start date: February 2026
Reference number: ZI.110.8.2025
Expected decision date: December 31, 2025

 

We are looking for candidates to join the Pathfinder research project funded by the European Innovation Council (Grant No. 101130715), titled: " Bottom-up manufacturing of artificial anti-tumor T cells (ArTCell)”. The project is conducted by an international consortium including KU Leuven, Belgium (project leader), Toscana Life Sciences Foundation, Siena, Italy, Max Planck Institute for Polymer Research, Mainz, Germany, and the Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw (IMDiK PAN). The research will be carried out at the Mossakowski Medical Research Institute, Polish Academy of Sciences, Department of Immunology, under the supervision of Dr. Małgorzata Firczuk, project leader at IMDiK PAN.

Tasks description
The project aims to develop synthetic replacements for T cells (ArTCell – artificial T cells), which mimic the function of natural T cells in fighting cancer. The goal is to create a safer, more efficient, and cost-effective alternative to current CAR-T (Chimeric Antigen Receptor T cell) therapies. ArTCells will be constructed from GUVs (Giant Unilamellar Vesicles) equipped with proteins enabling the recognition of cancer cells via CAR receptors and adhesion molecules, and capable of destroying them using proteins that induce tumor cell death. The research conducted at IMDiK PAN will focus on analyzing the biodistribution of ArTCells in mouse models and evaluating their anti-tumor efficacy in in vitro and in vivo tests.

Requirements

• PhD degree in biology, biotechnology, pharmacy, medical sciences, or related fields
• Hands-on experience, in particular: proficiency in flow cytometry, cell culture, and basic molecular biology techniques (immunoblotting, PCR, genetic modification of cells, cloning)
• Experience in working with in vivo tumor models, especially in mice
• Documented scientific achievements (publications)
• Excellent written and spoken English
• Accuracy, reliability, and strong organizational skills
• Good communication and teamwork skills
• Interest in immunology and oncology

Additional assets

• Experience in international and multidisciplinary collaborative projects
• Experience with immunotherapy-related projects

We offer

• Opportunity to gain valuable professional experience through participation in a prestigious EU-funded project
• Work in a large, diverse international team within the Department of Immunology at IMDiK PAN
• Attractive salary — up to 10,000 PLN net per month
• Friendly and supportive research environment promoting scientific development and teamwork

 

Applicants are requested to submit:

• a curriculum vitae,
• a motivation letter describing research interests and reasons for applying,
• and at least one reference letter from a former scientific supervisor or employer.

 

Reference number: ZI.110.8.2025

Send applications to: This email address is being protected from spambots. You need JavaScript enabled to view it.

Applications will be reviewed by the Recruitment Committee, chaired by the project leader.

The committee will evaluate candidates’ previous scientific achievements, research experience, and competence relevant to the project tasks.

 

 

               

 

 

INFORMATION CLAUSE ON PERSONAL DATA PROCESSING

Pursuant to Article 13 of Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation), Mossakowski Medical Research Institute, Polish Academy of Sciences hereby informs:

1. The Controller of your personal data is the Mossakowski Medical Research Institute, Polish Academy of Sciences, A. Pawińskiego 5 St., 02-106 Warsaw, Poland (“MMRI PAS”)

2. The Controller has designated the Data Protection Officer who can be contacted via the following e-mail address: This email address is being protected from spambots. You need JavaScript enabled to view it. or the post address of Controller.

3. Your personal data will be processed for the purpose of carrying out a recruitment process and selecting an employee and concluding a contract for employment at the MMRI PAS.

4. MMRI PAS processes Your personal data in relation to a legal obligation (the Article 6.1.c of the GDPR) pursuant to Article 221 § 1 of the Act of 26 June 1974 Labour Code or Your consent understood by sending them to MMRI PAS (the Article 6.1.a of the GDPR) for data not listed on Labour Code, and their application does not affect the possibility of participating in the recruitment / competition. If you do not want us to process additional data, please do not include it in the documents.

5. By submitting your candidacy, you consent to the fact that if you win the recruitment / competition, your name and surname together with information about the recommendation for employment will be posted on the MMRI PAS website.

6. Your application with personal data will be processed for period necessary for realization of purposes indicated in p. 3 - for a maximum of one month and then your application with personal data will be deleted.

7. With regard to processing of Your personal data for purposes mentioned in p. 3, Your personal data might by shared with following recipients or categories of recipients: entities supporting MMRI PAS in its business processes, in particular administrative and economic service and authorized entities.

8. Within the limits and on the terms set out in the GDPR, you have the right to request access to your personal data, rectification, deletion or limitation of processing, as well as the right to submit a declaration of withdrawal of consent to the processing of personal data at any time. Withdrawal of consent does not affect the lawfulness of the processing which was carried out on the basis of consent before its withdrawal, as well as the processing of data processed by the administrator on the basis of other provisions.

9. You have the right to lodge a complaint to the President of the Office for the Protection of Personal Data (ul. Stawki 2, 00-193 Warszawa).

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Deadline for applications: 31.10.2025
Expected starting date: November/December 2025
Procedure ID: ZKTS.110.1.2025

Project description
The project focuses on the purinergic P2X7 receptor (P2X7R) as a key molecular mediator of metabolic dysfunction and neuronal degeneration in Parkinson’s disease (PD). Accumulating evidence shows that α-synuclein (α-Syn) directly interacts with P2X7R, triggering calcium overload, oxidative stress, mitochondrial failure, and impaired glucose metabolism. Using a combination of in vivo PD models (α-Syn oligomer injection, behavioral testing, MRI) and in vitro studies (primary neuronal cultures, molecular and imaging techniques), we will dissect the role of P2X7R in:
• oxidative stress and redox homeostasis,
• mitochondrial quality control (mitophagy, mtUPR),
• central carbon metabolism,
• structural and behavioral changes in the PD brain.
The results are expected to uncover novel mechanisms of α-Syn neurotoxicity and establish P2X7R as a potential therapeutic target in PD.

Key responsibilities
• Planning and conducting in vivo and in vitro experiments (animal work, stereotactic surgery, behavioral tests, cell culture, transfection).
• Application of molecular biology and biochemical techniques (immunohistochemistry, confocal microscopy, mitochondrial isolation, Western blotting, PCR, enzymatic assays).
• Analysis and interpretation of results, preparation of manuscripts, and presentation of findings at national and international conferences.

Candidate requirements
• Ph.D. in neurobiology, neuropharmacology, molecular biology, or related field (within 7 years before start of employment).
• Proven experience in animal experimentation (valid ethical approval required) and cell culture techniques.
• Strong publication record (JCR-indexed journals) and conference activity.
• Fluent communication and writing in English.
• Knowledge of biochemical and molecular methods; ability to perform statistical analyses.
• Motivation for scientific work, independence, good organizational skills, and the ability to work in a team.

Additional assets: experience with neurodegenerative disease models, mitochondrial biology, or international research mobility.
Additional benefits: private health insurance, Multisport card, support for conference participation
Application
Applicants should send the following documents to This email address is being protected from spambots. You need JavaScript enabled to view it. 
• CV with full publication list,
• motivation letter including research interests,
• copy of Ph.D. diploma,
• contact details of at least one academic referee.

Apply via email to This email address is being protected from spambots. You need JavaScript enabled to view it. Please use the subject line: Application – Postdoc Position Neurobiology.
In the email title, please include: „ Scholarship grantee/Student” and procedure ID: ZKTS.110.1.2025

Procedure ID: ZKTS.110.1.2025
Deadline for applications: 31.10.2025
Expected starting date: November/December 2025
Duration: 36 months (with possible extension for an additional 12 months; first 6 months’ probation)
Salary: 8500 PLN gross/month + performance-based bonuses

We reserve the right to invite only selected candidates for interviews.

INFORMATION CLAUSE ON PERSONAL DATA PROCESSING
Pursuant to Article 13 of the Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation), Mossakowski Medical Research Institute, Polish Academy of Sciences hereby informs:
- The Controller of your personal data is the Mossakowski Medical Research Institute, Polish Academy of Sciences, A. Pawińskiego 5 St., 02-106 Warsaw, Poland (“MMRI PAS”)
- The Controller has designated the Data Protection Officer who can be contacted via the following e-mail address: This email address is being protected from spambots. You need JavaScript enabled to view it. or the post address of Controller.
- Your personal data will be processed for the purpose of carrying out a recruitment process and selecting an employee and concluding a contract for employment at the MMRI PAS.
- MMRI PAS processes Your personal data in relation to a legal obligation (the Article 6.1.c of the GDPR) pursuant to Article 221 § 1 of the Act of 26 June 1974 Labour Code or Your consent understood by sending them to MMRI PAS (the Article 6.1.a of the GDPR) for data not listed on Labour Code, and their application does not affect the possibility of participating in the recruitment / competition. If you do not want us to process additional data, please do not include it in the documents.
- By submitting your candidacy, you consent to the fact that if you win the recruitment / competition, your name and surname together with information about the recommendation for employment will be posted on the MMRI PAS website.
- Your application with personal data will be processed for period necessary for realization of purposes indicated in p. 3 - for a maximum of one month and then your application with personal data will be deleted.
- With regard to processing of Your personal data for purposes mentioned in p. 3, Your personal data might by shared with following recipients or categories of recipients: entities supporting MMRI PAS in its business processes, in particular administrative and economic service and authorized entities.
- Within the limits and on the terms set out in the GDPR, you have the right to request access to your personal data, rectification, deletion or limitation of processing, as well as the right to submit a declaration of withdrawal of consent to the processing of personal data at any time. Withdrawal of consent does not affect the lawfulness of the processing which was carried out on the basis of consent before its withdrawal, as well as the processing of data processed by the administrator on the basis of other provisions.
- You have the right to lodge a complaint to the President of the Office for the Protection of Personal Data (Stawki 2 St., 00-193 Warszawa).

 

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