Post-doctoral Researcher in Experimental Neurobiology / Neuropharmacology

Post-doctoral Researcher in Experimental Neurobiology / Neuropharmacology

City: Warsaw

Deadline for applications: 30.09.2026

Expected starting date: November/ December 2026

Procedure ID: ZKTS.110.1.2026

Project description
The project focuses on elucidating the role of the purinergic P2X7 receptor (P2X7R) in the development of metabolic dysfunction and neurodegeneration in Parkinson’s disease. Particular attention will be paid to the mechanisms through which pathological forms of α-synuclein activate P2X7R, leading to mitochondrial dysfunction, oxidative stress, and impaired cellular metabolism. The research will employ complementary, state-of-the-art in vivo and in vitro models, including an experimental model of Parkinson’s disease induced by α-synuclein oligomers, behavioural testing, magnetic resonance imaging, primary neuronal cultures, and advanced molecular, biochemical, and imaging techniques.

The main research areas will include:

  • regulation of oxidative stress and redox homeostasis;
  • mitochondrial quality-control mechanisms, including mitophagy and the mitochondrial unfolded protein response (mtUPR);
  • alterations in glucose metabolism and central carbon metabolism;
  • molecular, morphological, and functional consequences of P2X7R activation in the brain;
  • the relationship between metabolic dysfunction and the development of behavioural abnormalities in an experimental model of Parkinson’s disease.

The project integrates neurochemistry, mitochondrial biology, metabolomics, and research into the mechanisms of neurodegeneration. Its implementation will provide a deeper understanding of α-synuclein toxicity and help determine whether P2X7R may represent a novel therapeutic target in Parkinson’s disease.

Key responsibilities

  • Planning and conducting in vivo and in vitro experiments (animal work, stereotactic surgery, behavioral tests, cell culture).
  • Application of molecular biology and biochemical techniques (transfection, immunohistochemistry, confocal microscopy, mitochondrial isolation, Western blotting, PCR, enzymatic assays).
  • Analysis and interpretation of results, preparation of manuscripts, and presentation of findings at national and international conferences.

Candidate requirements

  • Ph.D. in neurobiology, neuropharmacology, molecular biology, or related field (within 7 years before start of employment)
  • proven experience in animal experimentation (valid ethical approval required) and/or cell culture techniques
  • strong publication record (JCR-indexed journals) and conference activity
  • fluent communication and writing in English
  • knowledge of biochemical and molecular methods; ability to perform statistical analyses
  • motivation for scientific work, independence, good organizational skills, and the ability to work in a team

Additional assets: experience with neurodegenerative disease models, mitochondrial biology, or international research mobility.

We offer:

  • employment at one of the leading scientific institutions in Poland
  • employment contract (full-time)
  • hybrid work arrangements
  • access to specialist equipment in the Institute
  • additional support from the social fund (i.e. support in difficult life situations, childcare subsidies and low interest loans)
  • possibility to join Employee Capital Plans (PPK)
  • additional benefits such as opportunity to join a group life insurance program, medical service package, and a Multisport card on preferential terms
  • work in a good team, in a nice atmosphere
  • friendly work environment

Application
Applicants should send the following documents:

  • CV with full publication list,
  • motivation letter including research interests,
  • copy of Ph.D. diploma,
  • contact details of at least one academic referee.

Apply via email to This email address is being protected from spambots. You need JavaScript enabled to view it. Please use the subject line: Application – Postdoc Position Neurobiology, procedure ID: ZKTS.110.1.2026

Procedure ID: ZKTS.110.1.2026
Deadline for applications: 30.09.2026

Expected starting date: November/December 2026

Duration: 36 months (with possible extension for an additional 12 months; first 6 months’ probation)
Salary: 8500 PLN gross/month + performance-based bonuses

We reserve the right to invite only selected candidates for interviews.

 

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