Head
Professor Leonora Buzanska, PhD, DSc, phone +48 22 66 85 250, This email address is being protected from spambots. You need JavaScript enabled to view it.


Secretariat
Agnieszka Włodarczyk, phone: +48 22 60 86 604, This email address is being protected from spambots. You need JavaScript enabled to view it.
Research staff
Magdalena Czeredys, PhD, phone +48 22 60 86 563, This email address is being protected from spambots. You need JavaScript enabled to view it. 

Magdalena Czeredys_Huntington's disease Group

Marta Kot, PhD, phone: +48 22 60 86 563, This email address is being protected from spambots. You need JavaScript enabled to view it.
Wioletta Lech, PhD, phone: +48 22 60 86 563, This email address is being protected from spambots. You need JavaScript enabled to view it.
Paweł Leszczyński, PhD, phone +48 22 608 66 04, This email address is being protected from spambots. You need JavaScript enabled to view it.
Valery Zayat , PhD, phone: +48 22 60 86 407, This email address is being protected from spambots. You need JavaScript enabled to view it.
Marzena Zychowicz, PhD, phone: +48 22 60 86 563, This email address is being protected from spambots. You need JavaScript enabled to view it.
Zuzanna Kuczyńska, MSc, phone: +48 22 60 86 604, This email address is being protected from spambots. You need JavaScript enabled to view it.
Technical Staff
Hanna Winiarska, phone: +48 22 60 86 563, This email address is being protected from spambots. You need JavaScript enabled to view it.
PhD students
Michał Liput, MSc, phone: +48 22 60 86 604, This email address is being protected from spambots. You need JavaScript enabled to view it.
Erkan Metin MSc, phone: +48 22 60 86 604
Graduate students
Aleksandra Duchnowska (SGGW)
Zuzanna Siek (SGGW)

Research profile

• Derivation of therapeutically competent stem cells: optimization of biomimetic culture conditions, „priming”, and biomimetic environment (three-dimensional culture, signaling molecules, and physiological normoxia)
• Preclinical studies of neuroprotective and anti-inflammatory potential of human mesenchymal stem cells (hMSC) ex vivo (organotypic hippocampal and spinal cord slides) and in vivo ( focal brain injury in rat) 
• The role of mitochondrial biogenesis during early neural development: research using brain organoids obtained from human induced pluripotent stem cells (hiPSCs)
• Application of new methods of stem cell bioengineering (reporter lines, genome editing) and their niche (control of physicochemical properties of 3D scaffolds) to study the molecular mechanisms of early neural development
• Geno- and embryo-toxicity induced by neurotoxins:: mechanistic and molecular mechanisms using human induced pluripotent stem cells (hiPSC) model of early development

Grants

• Linking Metabolic Response of Mitochondrial Biogenesis Induction Via Alpha 7 Nicotinic Acetylcholine Receptor Agonist in Human Familial Alzheimer`s Disease Dorsal Forebrain Organoid Model” the MMRI Research Fund grant no. FBW-08/2023, PI: Erkan Metin, Msc, 2023-2024

• "The effect of nuclear FGFR1 on the mitophagy and neural cell type specification in the human cortical organoid model", NCN PRELUDIUM 21, nr2022/45/N/NZ3/04202, PI: Michal Liput,Msc, Supervisor: prof. Leonora Bużańska,implementation period 2023-2025

• "Molecular engineering of PPARGC1A for controlling neuronal to glial switch in the development of cortical brain organoids",NCN PRELUDIUM 21, nr2022/45/N/NZ1/02754, PI: Zuzanna Kuczynska, Msc, Supervisor: prof. Leonora Bużańska,implementation period 2023-2025

• “Partial reprogramming of dopaminergic neurons in a model of cell aging dependent on pharmacological regulation of telomerase activity”, the MMRI Research Fund grant no. F-032, PI: Paweł Leszczyński, PhD, 2022-2023

• “The impact of intrastriatal transplantation of Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) on hippocampal neurogenesis in a rat model of stroke”, the MMRI Research Fund grant no. FBW 022/2021, PI: Marta Kot, PhD, 2021 – 2022
• „Biomaterials and advanced physical techniques for regenerative cardiology and neurology”, COST BIONECA Action WG4 network, Program of European Collaboration in the Field of Scientific and Technical Research, PI: prof. Leonora Buzanska, implementation period 2017- 2021
• „Effect of PGC1a on mitochondrial biogenesis and neural differentiation during the early stages of human brain organoid development”, NCN OPUS 18, nr 2019/35/B/NZ3/04383, PI: prof. Leonora Buzanska, implementation period 2020-2024
• „ Molecular evaluation of neuroprotective and regenerative properties of WJ-MSC cells after transplantation into a damaged rat brain”, NCN PRELUDIUM 18, nr 2019/35/N/NZ5/03723, PI: Wioletta Lech, Msc, Supervisor: prof. Leonora Bużańska, implementation period 2020-2023
• „Embryotoxicity and teratogenicity as a result of the DNA damage response in iPS cells: the effect of methylmercury chloride and low oxygen levels”, NCN Preludium 9, nr 2015/17/N/NZ7/04096, PI: Justyna Augustyniak, Ph.D., Supervisor: prof. Leonora Buzanska, implementation period 2015-2019
• „The role of mechanotransduction in the regulation of stem cell immunomodulation”, MINIATURA 3, nr 2019/03/X/NZ3/01109, PI: Marzena Zychowicz, Ph.D., Realization period 2020-2021
• „Generation of induced pluripotent cells (iPSCs) from patients with Dravet Syndrome for modeling neuronal plasticity in genetically inherited forms of epilepsy in children”, MINIATURA 3, nr 2019/03/X/NZ3/02139, PI: Valery Zayat, Ph.D., Realization period 2020-2021

Collaboration:
domestic

• Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Poland. Prof. Piotr Stepien. Topic: The influence of mitochondrial biogenesis on early neural development of human induced pluripotent stem cells (hiPSC)
• Centre of Biological and Chemical Sciences, University of Warsaw, Poland. Prof. Krystian Jazdzewski. Topic: Transcriptomics research using next-generation sequencing (RNA-Seq) for early neural differentiation of human iPSC cells
  
•  Department of General Pathology, Pomeranian Medical University, Poland. Prof. Bogdan Machalinski, Rector of Pomeranian Medical University, Head of Department of General Pathology. Topic: "Innovative strategy for diagnostics, prevention and adiuvant therapy of selected neurodegenerative disorders in population of Polish ancestry”- Strategmed II collaboration
• University of Warmia and Mazury in Olsztyn. Head of Division of Innovative Neurosurgery and Neurophysiology, Department of Neurosurgery and Stem Cell Research Laboratory in UWM. Prof. Wojciech Maksymowicz, Vice-Rector for the Medical Studies and Research. Topic: "Innovative strategy for diagnostics, prevention and adiuvant therapy of selected neurodegenerative disorders in population of Polish ancestry” - Strategmed II collaboration 
• Laboratory of Molecular Bases of Aging, Nencki Institute of Experimental Biology, PAS. Prof. Ewa Sikora. Topic: “Unravelling and Combating Neurodevelopmental Disorders (NDD) Using Induced Pluripotent Stem Cells (iPSC) and Cerebral Organoids”
  
  international 
• State University of New York in Buffalo, Molecular and Structural Neurobiology and Gene Therapy Lab. Prof. Michał Stachowiak, Director of Stem Cells Engraftment & In Vivo Analysis Facility, WNYSTEM State University of New York @ Buffalo. Topic: Studies on early neural development in the model of human cerebral organoids, in health and disease
• Universita Degli Studi Di Milano, Milan, Italy, Prof. Francesca Caloni, Head of Department of Veterinary Medicine. Topic: „Genotoxic response to MeHgCl of human induced pluripotent stem cells during neuronal development”, scientific exchange, Canaletto project 2016-2018
• Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. Prof. Magdalena Zernicka-Goetz, Head of Mammalian Embryo and Stem Cell Group. Topic: “Mechanisms of early neural development in the model of in vitro human embryogenesis based on iPS cells in a chemically-defined 3D culture”, EMBO Fellowship collaboration
• University of Modena e Reggio Emilia, Center for Regenerative Medicine, Modena, Włochy. Prof Graziella Pelegini. Topic: Developmental properties of human limbal stem cells at low oxygen tension conditions. Erasmus + collaboration
• University Milano Bicocca, Mediolan oraz "Maggiore della Carità" University Hospital, Novara, Italy. Prof. Angelo Vescovi, dr Daniela Ferrari, prof. Letizzia Mazzini. Topic: ”Implementation of human neural stem cells for therapy of the CNS: preclinical studies”. COST BIONECA Action WG4 network collaboration

Research equipment

• BioSpherix Xvivo X3 system for low oxygen culture
• CytoSMART Lux 10X AACS-1001 Cystosmart TM Lux 10X System
• Automatic cell counter (Invitrogen Countess automated cell counter C10227)
• Fluorescence microscope system (Mikroscope Axiovert 40c, Zeiss, coupled with Canon
• camera) 
• Preparative and analytical HPLC (High-Performance Liquid Chromatography) with UV-VIS detector
• Stereotaxic apparatus for rats with a microinjection pump

Research methods

• in vitro – stem cell culture: on the 2D bioactive domains of defined geometry (A), pseudo-3D conditions (adherent culture of neural stem cells on a hydrogel of basement membrane proteins, matrigel) (B), cerebral organoids derived from human iPSC (non-adherent culture, under agitation conditions) (C), and 3D supporting scaffolds: keratin (D), collagen (E) , fibrin (F);
• ex vivo - organotypic culture: model of injured hippocampal (G) and spinal cord (H);
• in vivo - rat model of focal brain injury (I);
• Molecular biology: RT-PCR, cloning, transduction, transfection, production of viral vectors, genome editing using the CRISPR/Cas9 method;
• Determination of protein level and cytokine concentration (Western blot, ELISA/Luminex, ICC/IHC);
• Pharmacokinetic and biochemical methods using the HPLC technique (e.g. metabolism of exogenous and endogenous substances);
• Preclinical studies in rodents: rat model of stroke, mouse model of tumorigenicity (biosafety and biodistribution of MSCs and iPSCs, intracerebral transplantation of stem cells).
  
  

Selected publications

• Kot M* Aryl Hydrocarbon Receptor Establishes a Delicate Balance between the Level of the Trace Amine Tryptamine and Monoamine Oxidase Activity in the Brain and Periphery in Health and Conditions such as Neurodegenerative, Neurodevelopmental, and Psychiatric Disorders. Current Neuropharmacology 2025Jan 13. doi: 10.2174/011570159X340635241022113450. Epub ahead of print. PMID: 39812050.
• Mazzini L*, De Marchi F, Buzanska L, Follenzi A, Glover JC, Gelati M, Lombardi I, Maioli M, Mesa-Herrera F, Mitrečić D, Olgasi C, Pivoriūnas A, Sanchez-Pernaute R, Sgromo C, Zychowicz M, Vescovi A, Ferrari D. Current status and new avenues of stem cell-based preclinical and therapeutic approaches in amyotrophic lateral sclerosis. Expert Opinion on Biological Therapy 2024 Sep;24(9):933-954. doi: 10.1080/14712598.2024.2392307. PMID: 39162129.
• Dhiman S, Manoj N, Liput M, Sangwan A, Diehl J, Balcerak A, Sudhakar S, Augustyniak J, Jornet JM, Bae Y, Stachowiak EK, Dutta A, Stachowiak MK*. Systems Genome: Coordinated Gene Activity Networks, Recurring Coordination Modules, and Genome Homeostasis in Developing Neurons. International Journal of Molecular Sciences 2024 May 22;25(11):5647. doi: 10.3390/ijms25115647. PMID: 38891836.
• Kuczynska Z, Neglur PK, Metin E, Liput M, Zychowicz M, Zayat V, Krześniak NE, Buzanska L, Kot M*. Safety of GMP-compliant iPSC lines generated by Sendai virus transduction is dependent upon clone identity and sex of the donor. Folia Neuropathologica 2024;62(1):32-46. doi: 10.5114/fn.2024.134026. PMID: 38741435.
• Naama M, Rahamim M, Zayat V, Sebban S, Radwan A, Orzech D, Lasry R, Ifrah A, Jaber M, Sabag O, Yassen Y, Khatib A, Epsztejn-Litman S, Novoselsky-Persky M, Makedonski K, Deri N, Goldman-Wohl D, Cedar H, Yagel S, Eiges R, Buganim Y*. Pluripotency-independent induction of human trophoblast stem cells from fibroblasts. Nature Communications 2023, doi: 10.1038/s41467-023-39104-1. PMID: 37291192.
• Augustyniak J, Kozlowska H, Buzanska L*: Genes Involved in DNA Repair and Mitophagy Protect Embryoid Bodies from the Toxic Effect of Methylmercury Chloride under Physioxia Conditions. Cells 2023 Jan 21;12(3):390. doi:10.3390/cells12030390, PMID: 36766732
• Zayat V, Kuczynska Z, Liput M, Metin E, Rzonca-Niewczas S, Smyk M, Mazurczak T, Goszczanska-Ciuchta A, Leszczynski P, Hoffman-Zacharska D, Buzanska L*: The Generation of Human iPSC Lines from Three Individuals with Dravet Syndrome and Characterization of Neural Differentiation Markers in iPSC-Derived Ventral Forebrain Organoid Model. Cells 2023 Jan 16;12(2):339. doi:10.3390/cells12020339, PMID: 36672274
• Kot M*, Neglur PK, Pietraszewska A, Buzanska L. Boosting Neurogenesis in the Adult Hippocampus Using Antidepressants and Mesenchymal Stem Cells. Cells 2022Oct 14;11(20):3234. doi: 10.3390/cells11203234. PMID: 36291101.
• Zayat V*, Szlendak R, Hoffman-Zacharska D. Concise Review: Stem Cell Models of SCN1A-Related Encephalopathies-Current Perspective and Future Therapies. Cells 2022 Oct 4;11(19):3119. doi: 10.3390/cells11193119. PMID: 36231081.
• Augustyniak J, Lipka G, Kozlowska H, Caloni F, Buzanska L*. Oxygen as an important factor modulating in vitro MeHgCl toxicity associated with mitochondrial genes in hiPSCs. Ecotoxicology and Environmental Safety 2022 Aug;241:113737. doi: 10.1016/j.ecoenv.2022.113737. Epub 2022 Jun 10. PMID: 35696963.
• Kuczynska Z, Metin E, Liput M, Buzanska L*. Covering the Role of PGC-1α in the Nervous System. Cells 2021 Dec 30;11(1):111. doi: 10.3390/cells11010111. PMID: 35011673.
• Liput M, Magliaro C, Kuczynska Z, Zayat V, Ahluwalia A, Buzanska L*. Tools and approaches for analyzing the role of mitochondria in health, development and disease using human cerebral organoids. Developmental Neurobiology 2021 Jul;81(5):591-607. doi: 10.1002/dneu.22818. Epub 2021 Apr 25. PMID: 33725382.
• Tomecka E#, Lech W#, Zychowicz M, Sarnowska A, Murzyn M, Oldak T, Domanska-Janik K, Buzanska L*, Rozwadowska N. Assessment of the Neuroprotective and Stemness Properties of Human Wharton's Jelly-Derived Mesenchymal Stem Cells under Variable (5% vs. 21%) Aerobic Conditions. Cells 2021 Mar 24;10(4):717. doi: 10.3390/cells10040717. PMID: 33804841.
• Kaminska A, Wedzinska A, Kot M, Sarnowska A*. Effect of Long-Term 3D Spheroid Culture on WJ-MSC. Cells 2021 Mar 24;10(4):719. doi: 10.3390/cells10040719. PMID: 33804895.
• Daujat-Chavanieu M, Kot M*. Albumin is a secret factor involved in multidirectional interactions among the serotoninergic, immune and endocrine systems that supervises the mechanism of CYP1A and CYP3A regulation in the liver. Pharmacology & Therapeutics 2020 Nov;215:107616. doi: 10.1016/j.pharmthera.2020.107616. Epub 2020 Jun 24. PMID: 32590025.
• Lech W, Sarnowska A, Kuczynska Z, Dabrowski F, Figiel-Dabrowska A, Domanska-Janik K, Buzanska L, Zychowicz M*. Biomimetic microenvironmental preconditioning enhance neuroprotective properties of human mesenchymal stem cells derived from Wharton's Jelly (WJ-MSCs). Scientific Reports 2020 Oct 9;10(1):16946. doi: 10.1038/s41598-020-74066-0. PMID: 33037314.
• Kosinski M, Figiel-Dabrowska A, Lech W, Wieprzowski L, Strzalkowski R, Strzemecki D, Cheda L, Lenart J, Domanska-Janik K, Sarnowska A*. Bone Defect Repair Using a Bone Substitute Supported by Mesenchymal Stem Cells Derived from the Umbilical Cord. Stem Cells International 2020 Apr 5;2020:1321283. doi: 10.1155/2020/1321283. PMID: 32300364.
• Augustyniak J, Bertero A, Coccini T, Baderna D, Buzanska L, Caloni F*. Organoids are promising tools for species-specific in vitro toxicological studies. Journal of Applied Toxicology 2019 Dec;39(12):1610-1622. doi: 10.1002/jat.3815. Epub 2019 Jun 5. PMID: 31168795.
• Bertero A, Augustyniak J, Buzanska L, Caloni F*. Species-specific models in toxicology: in vitro epithelial barriers. Environmental Toxicology and Pharmacology 2019 Aug;70:103203. doi: 10.1016/j.etap.2019.103203. Epub 2019 Jun 1. PMID: 31176950.
• Augustyniak J, Lenart J, Lipka G, Stepien PP, Buzanska L*. Reference Gene Validation via RT-qPCR for Human iPSC-Derived Neural Stem Cells and Neural Progenitors. Molecular Neurobiology 2019 Oct;56(10):6820-6832. doi: 10.1007/s12035-019-1538-x. Epub 2019 Mar 29. PMID: 30927132.
• Zychowicz M, Pietrucha K, Podobinska M, Kowalska-Wlodarczyk M, Lenart J, Augustyniak J, Buzanska L*. The collagen scaffold supports hiPSC-derived NSC growth and restricts hiPSC. Frontiers in Bioscience-Scholar (FBS) 2019 Mar 1;11(1):105-121. doi: 10.2741/S529. PMID: 30844739.
• Augustyniak J, Lenart J, Gaj P, Kolanowska M, Jazdzewski K, Stepien PP, Buzanska L. Bezafibrate Upregulates Mitochondrial Biogenesis and Influence Neural Differentiation of Human-Induced Pluripotent Stem Cells. Molecular Neurobiology 2019 Jun;56(6):4346-4363. doi: 10.1007/s12035-018-1368-2. Epub 2018 Oct 13. PMID: 30315479.
• Książka pt. “Human Neural Stem Cells: From Generation to Differentiation and Application” w serii Results and Problems in Cell Differentiation 66, 2018, Springer Nature, pod redakcją prof. dr hab. n. med. Leonory Bużańskiej (PDF)
• Janowska J, Gargas J, Ziemka-Nalecz M, Zalewska T, Buzanska L, Sypecka J*. Directed glial differentiation and transdifferentiation for neural tissue regeneration. Experimental Neurology 2019 Sep;319:112813. doi: 10.1016/j.expneurol.2018.08.010. Epub 2018 Aug 30. PMID: 30171864.
• Buzanska L*, Zychowicz M, Kinsner-Ovaskainen A. Bioengineering of the Human Neural Stem Cell Niche: A Regulatory Environment for Cell Fate and Potential Target for Neurotoxicity. Results and Problems in Cell Differentiation 2018;66:207-230. doi: 10.1007/978-3-319-93485-3_9. PMID: 30209661.
• Eve DJ*, Sanberg PR, Buzanska L, Sarnowska A, Domanska-Janik K*. Human Somatic Stem Cell Neural Differentiation Potential. Results and Problems in Cell Differentiation 2018;66:21-87. doi: 10.1007/978-3-319-93485-3_2. PMID: 30209654.
• Mazzini L*, Ferrari D, Andjus PR, Buzanska L, Cantello R, De Marchi F, Gelati M, Giniatullin R, Glover JC, Grilli M, Kozlova EN, Maioli M, Mitrečić D, Pivoriunas A, Sanchez-Pernaute R, Sarnowska A, Vescovi AL; BIONECA COST ACTION WG Neurology. Advances in stem cell therapy for amyotrophic lateral sclerosis. Expert Opinion on Biological Therapy 2018 Aug;18(8):865-881. doi: 10.1080/14712598.2018.1503248. PMID: 30025485.
• Kuzma-Kozakiewicz M, Marchel A, Kaminska A, Gawel M, Sznajder J, Figiel-Dabrowska A, Nowak A, Maj E, Krzesniak NE, Noszczyk BH, Domanska-Janik K, Sarnowska A*. Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts' Recommendations: Choosing Optimal Monitoring Tools. Stem Cells International 2018 Aug 12:4392017. doi: 10.1155/2018/4392017. PMID: 30158984.
• Dabrowska S, Sypecka J, Jablonska A, Strojek L, Wielgos M, Domanska-Janik K, Sarnowska A*. Neuroprotective Potential and Paracrine Activity of Stromal Vs. Culture-Expanded hMSC Derived from Wharton Jelly under Co-Cultured with Hippocampal Organotypic Slices. Molecular Neurobiology 2018 Jul;55(7):6021-6036. doi: 10.1007/s12035-017-0802-1. Epub 2017 Nov 13. PMID: 29134515.
• Huang H*, Young W, Chen L, Feng S, Zoubi ZMA, Sharma HS, Saberi H, Moviglia GA, He X, Muresanu DF, Sharma A, Otom A, Andrews RJ, Al-Zoubi A, Bryukhovetskiy AS, Chernykh ER, Domańska-Janik K, Jafar E, Johnson WE, Li Y, Li D, Luan Z, Mao G, Shetty AK, Siniscalco D, Skaper S, Sun T, Wang Y, Wiklund L, Xue Q, You SW, Zheng Z, Dimitrijevic MR, Masri WSE, Sanberg PR, Xu Q, Luan G, Chopp M, Cho KS, Zhou XF, Wu P, Liu K, Mobasheri H, Ohtori S, Tanaka H, Han F, Feng Y, Zhang S, Lu Y, Zhang Z, Rao Y, Tang Z, Xi H, Wu L, Shen S, Xue M, Xiang G, Guo X, Yang X, Hao Y, Hu Y, Li J, Ao Q, Wang B, Zhang Z, Lu M, Li T. Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017). Cell Transplantation 2018 Feb;27(2):310-324. doi: 10.1177/0963689717746999. PMID: 29637817.
• Janowska J, Gargas J, Ziemka-Nalecz M, Zalewska T, Buzanska L, Sypecka J*. Directed glial differentiation and transdifferentiation for neural tissue regeneration. Experimental Neurology 2019 Sep; 319:112813. doi: 10.1016/j.expneurol.2018.08.010. Epub 2018 Aug 30. PMID: 30171864
• Pietrucha K, Zychowicz M, Podobinska M, Buzanska L*. Functional properties of different collagen scaffolds to create a biomimetic niche for neurally committed human induced pluripotent stem cells (iPSC). Folia Neuropathologica 2017;55(2):110-123. doi: 10.5114/fn.2017.68578. PMID: 28677368.
• Augustyniak J, Lenart J, Zychowicz M, Stepien PP, Buzanska L*. Mitochondrial biogenesis and neural differentiation of human iPSC is modulated by idebenone in a developmental stage-dependent manner. 2017 Aug;18(4):665-677. doi: 10.1007/s10522-017-9718-4. Epub 2017 Jun 22. PMID: 28643190.
• Augustyniak J, Lenart J, Zychowicz M, Lipka G, Gaj P, Kolanowska M, Stepien PP, Buzanska L*. Sensitivity of hiPSC-derived neural stem cells (NSC) to Pyrroloquinoline quinone depends on their developmental stage. Toxicology in Vitro 2017 Dec;45 (Pt 3):434-444. doi: 10.1016/j.tiv.2017.05.017. PMID: 28578007.
• Podobinska M, Szablowska-Gadomska I, Augustyniak J, Sandvig I, Sandvig A, Buzanska L. Epigenetic Modulation of Stem Cells in Neurodevelopment: The Role of Methylation and Acetylation. Frontiers in Cellular Neuroscience 2017 Feb 7;11:23. doi: 10.3389/fncel.2017.00023. PMID: 28223921.
• Sandvig I, Gadjanski I, Vlaski-Lafarge M, Buzanska L, Loncaric D, Sarnowska A, Rodriguez L, Sandvig A, Ivanovic Z*. Strategies to Enhance Implantation and Survival of Stem Cells After Their Injection in Ischemic Neural Tissue. Stem Cells and Development 2017 Apr 15;26(8):554-565. doi: 10.1089/scd.2016.0268. Epub 2017 Jan 18. PMID: 28103744.
• Krupska O, Sarnowska A, Fedorczyk B, Gewartowska M, Misicka A, Zablocka B, Beresewicz M*. Ischemia/Reperfusion-Induced Translocation of PKCβII to Mitochondria as an Important Mediator of a Protective Signaling Mechanism in an Ischemia-Resistant Region of the Hippocampus. Neurochemical Research 2017 Aug;42(8):2392-2403. doi: 10.1007/s11064-017-2263-3. Epub 2017 Apr 12. PMID: 28401402.
• Drela K, Lech W, Figiel-Dabrowska A, Zychowicz M, Mikula M, Sarnowska A, Domanska-Janik K*. Enhanced neuro-therapeutic potential of Wharton's Jelly-derived mesenchymal stem cells in comparison with bone marrow mesenchymal stem cells culture. 2016 Apr;18(4):497-509. doi: 10.1016/j.jcyt.2016.01.006. PMID: 26971678.
• Obtulowicz P, Lech W, Strojek L, Sarnowska A, Domanska-Janik K*. Induction of Endothelial Phenotype From Wharton's Jelly-Derived MSCs and Comparison of Their Vasoprotective and Neuroprotective Potential With Primary WJ-MSCs in CA1 Hippocampal Region Ex Vivo. Cell Transplantation 2016;25(4):715-27. doi: 10.3727/096368915X690369. Epub 2015 Dec 31. PMID: 26722842.
• Lech W, Figiel-Dabrowska A, Sarnowska A*, Drela K, Obtulowicz P, Noszczyk BH, Buzanska L, Domanska-Janik K. Phenotypic, Functional, and Safety Control at Preimplantation Phase of MSC-Based Therapy. Stem Cells International 2016; 2016:2514917. doi: 10.1155/2016/2514917. Epub 2016 Aug 29. PMID: 27651796.
• Sypecka J*, Sarnowska A. Mesenchymal cells of umbilical cord and umbilical cord blood as a source of human oligodendrocyte progenitors. Life Sciences 2015 Oct 15;139:24-9. doi: 10.1016/j.lfs.2015.08.006. Epub 2015 Aug 15. PMID: 26285174.
• Gornicka-Pawlak E*, Janowski M, Jablonska A, Sypecka J, Domanska-Janik K. Complex assessment of distinct cognitive impairments following ouabain injection into the rat dorsoloateral striatum. Behavioural Brain Research 2015 Aug 1;289:133-40. doi: 10.1016/j.bbr.2015.03.061. Epub 2015 Apr 3. PMID: 25845737.
• Sypecka J, Koniusz S, Kawalec M, Sarnowska A*. The organotypic longitudinal spinal cord slice culture for stem cell study. Stem Cells International 2015; 2015:471216. doi: 10.1155/2015/471216. Epub 2015 Jan 31. PMID: 25802530.
• Janowski M, Walczak P, Kropiwnicki T, Jurkiewicz E, Domanska-Janik K, Bulte JW, Lukomska B, Roszkowski M*. Long-term MRI cell tracking after intraventricular delivery in a patient with global cerebral ischemia and prospects for magnetic navigation of stem cells within the CSF. PLoS One 2014 Jun 11;9(2):e97631. doi: 10.1371/journal.pone.0097631. PMID: 24919061.
• Zychowicz M, Dziedzicka D, Mehn D, Kozlowska H, Kinsner-Ovaskainen A, Stępień PP, Rossi F, Buzanska L*. Developmental stage dependent neural stem cells sensitivity to methylmercury chloride on different biofunctional surfaces. Toxicology in Vitro 2014 Feb;28(1):76-87. doi: 10.1016/j.tiv.2013.06.023. Epub 2013 Jul 17. PMID: 23872426.
• Drela K, Sarnowska A, Siedlecka P, Szablowska-Gadomska I, Wielgos M, Jurga M, Lukomska B, Domanska-Janik K*. Low oxygen atmosphere facilitates proliferation and maintains undifferentiated state of umbilical cord mesenchymal stem cells in an hypoxia inducible factor-dependent manner. Cytotherapy. 2014 Jul;16(7):881-92. doi: 10.1016/j.jcyt.2014.02.009. Epub 2014 Apr 13. PMID: 24726658.
• Augustyniak J, Zychowicz M, Podobinska M, Barta T, Buzanska L*. Reprogramming of somatic cells: possible methods to derive safe, clinical-grade human induced pluripotent stem cells. Acta Neurobiologiae Experimentalis 2014;74(4):373-82. doi: 10.55782/ane-2014-2000. PMID: 25576968.