Conference & workshops - Rare diseases

We cordially invite you to participate in a free conference on rare diseases: "Diseases you can't see."

The scientific conference and workshop session will be held online on February 28^th and March 1^st.

This event is organized for the fifth time on the occasion of the World Rare Disease Day. This year, our Institute joined the group of co-organizers: the Institute of Biochemistry and Biophysics Polish Academy of Sciences, the EB Polska Foundation, the Institute of Mother and Child and the Polish Biochemical Society.

To read more about rare diseases and the Rare Disease Day, plese visit:

Rare Disease Day 2022 – Raising awareness for patients, families and carers around the world that are affected by rare diseases. 

To register, just click on the image below:

assistant professor/ professor of the institute/ professor* and Head of the Molecular Biology Unit

Job Vacancy is announced

by the Director of Mossakowski Medical Research Institute, Polish Academy of Sciences

for the position of

assistant professor or professor of the institute or professor*

and Head of the Molecular Biology Unit

 

City: Warsaw

Scientific discipline: medical sciences

Announcement date: April 3^rd, 2024

Application deadline: April 17^th, 2024

Expected date of competition results announcement: the end of April/beginning of May 2024

Date of taking the position: May 2024

 Keywords: brain ischemia, neuromuscular disorders, animal models of human diseases, in vitro models of brain ischemia, mitochondria, neurodegeneration, neuroprotection, signal transduction.

 

* Depending on the assessment of the candidate's qualifications, the Recruitment Committee may recommend employment as an assistant professor or professor of the institute or professor.

The Director of Mossakowski Medical Research Institute, Polish Academy of Sciences announces the competition for the position of the assistant professor or professor of the institute or professor* and Head of the Molecular Biology Unit to operationalize statutory tasks, conduct research projects and implement one’s vision of scientific development of the Unit.

Current research program of the Molecular Biology Unit:

Studying the role of mitochondria in ischemic signal transduction in the transient brain ischemia models leading to neurodegeneration and neuroprotection.

Description of activities:

• managing the Molecular Biology Unit,
• proposing and implementing own research topics using a modern methodology,
• research team formation,
• supervision all the tasks carried out by the Unit employees,
• obtaining external funds for research projects,
• publishing the results of scientific research,
• active participation in the scientific activities of the MMRI PAS and scientific community,
• introduction of new research technologies to raise the level of scientific research.

 The necessary qualification requirements for the Head of the Unit position:

• minimum of a Ph.D. degree in biological, medical or related sciences,
• expertise in etiopathology of human diseases and animal models of these diseases, designing new methods of therapy, planning and conducting preclinical studies and assessing the effectiveness of the therapies used, expertise and practical skills in histological and immunohistochemical techniques, working with laboratory animals, performing experiments and surgeries in animals, laboratory testing including analysis of human and animal material, imaging techniques, molecular biology and in vitro testing, application of multiplex molecular diagnostic tools,
• proven track record in securing research funding,
• demonstrated experience in managing research projects or leading scientific team,
• ability to propose innovative research topics using a modern methodologies,
• multidisciplinary research interests and experience,
• flexibility to adapt research profiles in response to public demand,
• scientific accomplishments evidenced by publications in international scientific journals as the first and/or corresponding author,
• experience in designing publication strategies,
• active participation in conferences and documented contributions,
• experience in science outreach and popularization,
• proficiency in English.

 

Additional requirements (desirable):

• ability to work as a team member,
• experience of working in an environment oriented towards practical implementation of scientific research,
• experience in supervising students and junior researchers,
• scientific cooperation with other research centers.

 Requirements for the position of the assistant professor:

• at least a Ph.D. degree in biological, medical or related sciences,
• at least 2 original articles in scientific journals indexed in JCR, including at least one of which the candidate is the first author, the first equal author or a corresponding author, published after obtaining the Ph.D. degree, but not containing the results of the Ph.D. thesis.

 Requirements for the position of professor of the institute or professor:

• habilitated doctor’s degree or title of professor, in the case of a person permanently residing abroad - at least a doctoral degree, in biological, medical or related sciences,
• at least 1 original article published after habilitation in scientific journals indexed in JCR, including at least one of which the candidate is the first author, the first equal author or a corresponding author,
• documented experience in obtaining funds,
• previous management of a research team or research project funded by external sources,
• only a person with the academic title of professor is employed in the position of professor based on the appointment made by the President of the Polish Academy of Sciences.

 

We offer:

• employment contract (full-time) and the position of the head of the Molecular Biology Unit (for non-MMRI employees),
• the position of the head of the Molecular Biology Unit and potential promotion (applicable for MMRI employees currently employed full-time),
• independence in the formation of the scientific and research profile of the team,
• access to specialist equipment in the Institute,
• friendly work environment.

Required documents:

• application to the Director to be entrusted with the function under the competition,
• documents to prove professional qualifications required for the position in question, including document confirming being a scientific degree or title holder,
• a cover letter containing information concerning scientific interest, scientific independence including participation in publications and grants, team management and development program, description of the planned staff management strategy as well as financing operations, functioning and development of the unit the applicant is applying for,
• the applicant’s CV including information about education, an occupational and scientific career as well as research, teaching, and organizational achievements,
• list of publications: publications before the doctorate, publications including doctorate’s results, publications after doctorate and after habilitation, and the bibliometric analysis; other documents to prove the applicant’s scientific achievements required in “Regulations of the employment for the scientific positions in MMRI PAS”, appropriate for the position to which the competition relates,
• a statement that Mossakowski Medical Research Institute, Polish Academy of Sciences shall be the applicant’s primary place of employment and the managerial function shall be performed full-time,
• documents confirming the fulfillment of other requirements specified in the announcement of the competition for the position in this competition announcement.

 

How to apply:

The application should be addressed to the Director of Mossakowski Medical Research Institute, Polish Academy of Sciences. The required documents in electronic form (pdf format only) should be sent to the following e-mail address: This email address is being protected from spambots. You need JavaScript enabled to view it. and must be received by the Institute by April 17^th, 2024.

Please include the following job offer identification number in your application: SDI.111.3.2024

The date of receipt of documents by MMRI PAS is decisive - the applications received after the deadline will not be considered.

Anticipated result announcement date: the end of April/beginning of May 2024.

Envisaged job starting date: May 2024.

The competition for the post of the assistant professor or professor of the institute or professor and head of the department is carried out in accordance with “Regulations of the competition for the position of a head of the research unit in MMRI PAS” and “Regulations of the employment for the scientific positions in MMRI PAS”.

 

COMPETITION RESULTS ANNOUNCEMENT

 

INFORMATION CLAUSE ON PERSONAL DATA PROCESSING

Under Article 13 of Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons concerning the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation), Mossakowski Medical Research Institute, Polish Academy of Sciences hereby informs:

• The Controller of your data is the Mossakowski Medical Research Institute, Polish Academy of Sciences, A. Pawińskiego 5 St., 02-106 Warsaw, Poland (“MMRI PAS”)
• The Controller has designated the Data Protection Officer who can be contacted via the following e-mail address: This email address is being protected from spambots. You need JavaScript enabled to view it. or the postal address of the Controller.
• Your data will be processed to carry out a recruitment process and select an employee and conclude a contract for employment at the MMRI PAS.
• MMRI PAS processes Your data concerning a legal obligation (Article 6.1.c of the GDPR) according to Article 221 § 1 of the Act of 26 June 1974 Labour Code or Your consent understood by sending them to MMRI PAS (Article 6.1.a of the GDPR) for data not listed on Labour Code, and their application does not affect the possibility of participating in the recruitment/competition. If you do not want us to process additional data, please do not include it in the documents.
• By submitting your candidacy, you consent to the fact that if you win the recruitment/competition, your name and surname together with information about the recommendation for employment will be posted on the MMRI PAS website.
• Your application with personal data will be processed for the period necessary for the realization of purposes indicated in p. 3 - for a maximum of one month and then your application with personal data will be deleted.
• Concerning processing of Your data for purposes mentioned in p. 3, Your data might be shared with the following recipients or categories of recipients: entities supporting MMRI PAS in its business processes, in particular administrative and economic service and authorized entities.
• Within the limits and on the terms set out in the GDPR, you have the right to request access to your data, rectification, deletion, or limitation of processing, as well as the right to submit a declaration of withdrawal of consent to the processing of personal data at any time. Withdrawal of consent does not affect the lawfulness of the processing which was carried out based on consent before its withdrawal, as well as the processing of data processed by the administrator based on other provisions.
• You have the right to lodge a complaint to the President of the Office

Scholarships for undergraduate students

 

Laboratory of Human Disease Multiomics at MMRI PAS is seeking 2 undergraduate students for scientific scholarships in the NCN Opus Project “Oncogene competition - a new interplay mechanism of mutant p53 with CMYC and mutant KRAS in human cancers”.

The stipend is planned for maximum 2 years, starting Jaunary 1st 2025; each stipend - 2500 PLN gross/month. The project is multidisciplinary, biomedical, includes collaborations and will allow to learn and develop skills of open and flexible scientific approach.

Requirements:

• Being a student during of the final 3 years of the full-time M.Sc./M.D. university program in biology, biotechnology, biomedicine, medicine or a similar subject.
• Good command of English and basic practice in scientific writing/presentation of data in English.
• Basic knowledge of molecular biology techniques (e.g. qPCR, RNA handling, western blot etc.) and basic cell culture methods.
• Basic knowledge of handling 3D/organoid cultures.
• Possibility to work on site for a few hours a day on workdays in Warsaw, Poland for the 2 following years.
  
  
  How to apply: Until 20th of December 2024 – please send the CV to dr Dawid Walerych: This email address is being protected from spambots. You need JavaScript enabled to view it.. Do not write a separate motivation letter – if you want to o justify your application, do so briefly in the e-mail in English.

The project: Among the universal driver oncogenes are mutated KRAS, hyperactive CMYC and mutated TP53, last of which upon acquiring missense mutations switches from a tumor suppressor to a potent driver oncogene. It has been shown by our group and in various other studies that these and other oncogenic drivers cooperate and complement one another to promote cell transformation and progression of neoplasias. In the same time it is a paradigm that this cooperation and ability of each driver oncogene to be decisive in oncogenesis is different dependent on the molecular background.

During an ongoing project our group has discovered in cancer cell lines that an important dimension of the molecular background is an “oncogene competition” phenomenon – when one oncogene is taking-over or inhibiting the activity of another oncogene which results in reshaping of molecular programs of both oncogenes.

This phenomenon has never been described before in cancer research and requires a large-scale and mechanism study using normal/cancer cell lines, cancer organoid cultures and in vivo validation in mice.

Post-doctoral Research Associate in the Laboratory of Molecular and Cellular Nephrology

 

Mossakowski Medical Research Institute, Polish Academy of Sciences

is seeking a candidate for a position of

 Post-doctoral Research Associate

 Recruitment is related to the project “The role of neutrophil serine proteases in the regulation of function of the podocyte and glomerular filtration barrier.”
OPUS no. 2021/41/B/NZ4/02797 funded by National Science Centre, Poland, carried out in the Laboratory of Molecular and Cellular Nephrology MMRI PAS.

City: Gdańsk                                                                                               
Scientific discipline: medical sciences
Announcement date: 08^th February 2024
Application deadline: 15^th February 2024
Link to the website: www.imdik.pan.pl

Keywords: post-doc, podocyte, insulin resistance, diabetes, albuminuria, gasdermin D, elastase, proteinase 3, cathepsin C, pyroptosis

The area of the research in which the candidate would participate:

      Diabetic nephropathy is one of the most common and serious complications of diabetic kidney disease. However, our knowledge of the causes and mechanisms of this form of nephropathy is still very limited. Disturbance of podocytes function has a central role in the development of proteinuria in diabetic nephropathy. Additionally, it has been known that increased activity of proteolytic enzymes promotes injury to the renal filtration barrier and renal dysfunction. The principal goal of this project is to define the role of neutrophil serine proteases in the development of pathological changes in the renal filtration barrier observed in diabetes, which eventually lead to diabetic nephropathy and kidney failure.

     The research project is divided into two parts: in vivo and in vitro. In the in vivo study, we will use ZDSD rat model and knockout CTSC-/- mouse model. Model ZDSD displays type 2 diabetes progression similar to the human disease – prediabetes (8-16 weeks of age), through overt diabetes (>16 weeks of age), to diabetic complications (24 weeks of age). In experiments in vitro, we will use kidney glomeruli and podocytes isolated from Wistar rats and immortalized lines of podocytes (mice and human). The functional, biochemical and molecular studies will aim to determine the role of serine proteases in regulation of function and structure of the podocyte in diabetes.

Description of duties:

• Planning and implementation of research tasks in accordance with the schedule of the project,
• Designing and conducting experiments with the use of biochemistry and molecular biology,
• Analysis of obtained data,
• Presenting the results at the group meetings, external seminars and scientific conferences,
• Preparation of scientific publications.

Necessary Requirements:

• PhD degree in biological sciences, pharmacological sciences, medical sciences, chemical sciences or relevant,
• Documented scientific achievements including publications in journals from JCR list,
• Participation in scientific conferences and internships,
• Experience in laboratory techniques in biochemistry, molecular biology,
• Working knowledge of statistical software (e.g. GraphPad Prism),
• Ability to work in a team and independently,
• Excellent knowledge of English, allowing effective communication and preparation of scientific manuscripts,
• Indication of Mossakowski Medical Research Institute Polish Academy of Sciences as a first place of employment.

Desirable Requirements:

• Experience in work with animal models (relevant certificates or trainings),
• Experience in substantive care for students and junior scientists.

We offer:

• Fixed-term employment contract, full-time replacement,
• Contract period: 01^st Marth 2024 – 31^st August 2024,
• Gross salary: around 7800 PLN / month,
• The opportunity to work in a pleased atmosphere, in a dynamic, developmental research group,
• Opportunity to participate and present obtained results at international conferences.

Required documents:

• Motivation letter with description of candidate’s scientific interests, scientific work, scientific independency, participation in research grants,
• CV listing candidate’s education, professional experience, scientific achievements, authored or co-authored publications and conference abstracts, internships and training,
• Copy of the PhD (or equivalent) diploma.

How to Apply:

The Application should be addressed to the Director of Mossakowski Medical Research Institute, Polish Academy of Sciences.

Please send your documents to This email address is being protected from spambots. You need JavaScript enabled to view it. include the following job offer identification number in your application: PMKN.110.1.2024

For more information about the project, please contact dr hab. Agnieszka Piwkowska This email address is being protected from spambots. You need JavaScript enabled to view it.

Expected date of the interview: 16^th February 2024
Expected decision date: 19^th February 2024
Expected job starting date: 01^st March 2024

INFORMATION CLAUSE ON PERSONAL DATA PROCESSING

Pursuant to Article 13 of Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation), Mossakowski Medical Research Institute, Polish Academy of Sciences hereby informs:

• The Controller of your personal data is the Mossakowski Medical Research Institute, Polish Academy of Sciences, A. Pawińskiego 5 St., 02-106 Warsaw, Poland (“MMRI PAS”)
• The Controller has designated the Data Protection Officer who can be contacted via the following e-mail address: This email address is being protected from spambots. You need JavaScript enabled to view it. or the post address of Controller.
• Your personal data will be processed for the purpose of carrying out a recruitment process and selecting an employee and concluding a contract for employment at the MMRI PAS.
• MMRI PAS processes Your personal data in relation to a legal obligation (the Article 6.1.c of the GDPR) pursuant to Article 22¹ 1 of the Act of 26 June 1974 Labour Code or Your consent understood by sending them to MMRI PAS (the Article 6.1.a of the GDPR) for data not listed on Labour Code, and their application does not affect the possibility of participating in the recruitment / competition. If you do not want us to process additional data, please do not include it in the documents.
• By submitting your candidacy, you consent to the fact that if you win the recruitment / competition, your name and surname together with information about the recommendation for employment will be posted on the MMRI PAS website.
• Your application with personal data will be processed for period necessary for realization of purposes indicated in p. 3 - for a maximum of one month and then your application with personal data will be deleted.
• With regard to processing of Your personal data for purposes mentioned in p. 3, Your personal data might by shared with following recipients or categories of recipients: entities supporting MMRI PAS in its business processes, in particular administrative and economic service and authorized entities.
• Within the limits and on the terms set out in the GDPR, you have the right to request access to your personal data, rectification, deletion or limitation of processing, as well as the right to submit a declaration of withdrawal of consent to the processing of personal data at any time. Withdrawal of consent does not affect the lawfulness of the processing which was carried out on the basis of consent before its withdrawal, as well as the processing of data processed by the administrator on the basis of other provisions.
• You have the right to lodge a complaint to the President of the Office for the Protection of Personal Data (ul. Stawki 2, 00-193 Warszawa).