Projects implemented in MMRI PAS funded by the National Science Centre (NCN):
The OPUS call for research projects:
Control of microRNAome maturation and its application in cancer stem cells targeted therapy
Project manager: Jakub Godlewski MD PhD
OPUS 20, implementation period: 2021 – 2025, project funding: PLN 2 987 254
Delivery of immune activators to phagocytic cells to induce antitumor immune response
Project manager: Tomasz Rygiel MD PhD
Project partner: Wrocław University of Science and Technology
OPUS 20, implementation period: 2021 – 2025, project funding: PLN 2 485 532
The importance of SAT1 glutamine transporter in the maintenance of glutamate and GABA homeostasis: implications for anxiety disorders
Project manager: Prof. Magdalena Zielińska MD PhD
OPUS 20, implementation period: 2021 - 2024, project funding: PLN 1 747 960
The impact of PGC1a on mitochondrial biogenesis and neural differentiation in early stages of human cerebral organoids development
Project manager: Prof. Leonora Bużańska MD PhD
OPUS 18, implementation period: 2020-2024, project funding: PLN 2 394 840
Increase of the therapeutic efficacy of anti-CD20 antibodies in B-acute lymphoblastic leukemia
Project manager: Małgorzata Firczuk MD PhD
Project partner: Princess Maxima Center, Utrecht
International collaboration: The Netherlands
OPUS 18, implementation period: 2020 – 2023, project funding: PLN 1 819 368
Role of oxidative stress in adoptive therapy with the application of chimeric antigen receptors
Project manager: dr Małgorzata Bajor
Project partner: Technical University of Dresden; Oslo University Hospital
International collaboration: Niemcy, Norwegia
OPUS 17, implementation period: 2020 – 2023, project funding: PLN 1 890 200
The impact of lactate and metabolic sensor GPR81 on the regulation of the function of the podocytic cell and the glomerular filtration barrier in normo- and hyperglycaemia
Project manager: Agnieszka Piwkowska MD PhD
OPUS 17, implementation period: 2020 – 2023; project funding: PLN 1 656 195
The role of BET proteins in the regulation of microglia cell-dependent neurodegeneration processes – the significance for pathomechanisms of Alzheimer's disease.
Project manager: Grzegorz Czapski MD PhD
OPUS 16, implementation period: 2019 – 2022; project funding: PLN 1 493 540
Epigenetic regulation of oestrogen metabolism in adipose tissue in patients with obesity
Project manager: Alina Kuryłowicz MD PhD
OPUS 16, implementation period: 2019 – 2023, project funding: PLN 626 650
The mutual interactions between WJ-MSC and fNSC affect the formation of a cell niche and regenerative abilities.
Project manager: Anna Sarnowska MD PhD
OPUS 16, implementation period: 2019 – 2022, project funding: PLN 1 867 380
The role of non-coding RNA in modification of the epigenetic mechanisms of neoplasm
Project manager: Agnieszka Bronisz MD PhD
OPUS 15, implementation period: 2019 – 2022, project funding: PLN 2 600 500
The role of klotho and NPP1 proteins in the regulation of podocytes function.
Project manager: Agnieszka Piwkowska MD PhD
Project partner: University of Gdańsk
OPUS 15, implementation period: 2019 – 2022, project funding: PLN 2 320 560
The search for new genes conditioning the predisposition to perform certain types of physical effort.
Project manager: Prof. Cezary Żekanowski MD PhD representing MMRI PAS (Leader: Gdansk University of Physical Education and Sport)
Project partner: Gdansk University of Physical Education and Sport
OPUS 14, implementation period: 2018 - 2021, project funding: PLN 1 513 400
Histone deacetylase inhibitors potential modulators of cerebral inflammatory response after neonatal asphyxia in rats.
Project manager: Małgorzata Nałęczas MD PhD
OPUS 14, implementation period: 2018 – 2022, project funding: PLN 801 847
Radiopharmaceuticals based on tachykinin-1 receptor antagonists for diagnosis and therapy of brain tumour: glioblastoma multiforme
Project manager: Prof. Aleksandra Misicka – Kęsik MD PhD
Project partner: Institute of Nuclear Chemistry and Technology
OPUS 13, implementation period: 2018 – 2022, project funding: PLN 961 230
Peroxyredoxins as potential therapeutic targets in treatment of glioblastoma multiforme.
Project manager: Monika Szeliga MD PhD
OPUS 13, implementation period: 2018 – 2022, project funding: PLN 602 700
Identification and therapeutic use of proteasome-regulated molecular pathways in human neoplastic diseases
Project manager: Dawid Walerych MD PhD
OPUS 13, implementation period: 2018 – 2022, project funding: PLN 1 293 600
The role of the interaction between purine P1 receptors and the bioavailability of nitric oxide in the regulation of intrarenal blood circulation and renal excretion in diabetes mellitus in an animal model
Project manager: Leszek Dobrowolski MD PhD
OPUS 13, implementation period: 2018 – 2021, project funding: PLN 573 400
The significance of impaired signalling dependent on extracellular nucleoside and nucleotide receptors in synaptic dysfunction in autism
Project manager: Agata Adamczyk MD PhD
OPUS 13, implementation period: 2018 – 2022, project funding: PLN 998 390
Identification and characteristics of genome variants associated with Gilles de la Tourette syndrome.
Project manager: Prof. Cezary Żekanowski MD PhD
OPUS 12, implementation period: 2017 – 2021, project funding: PLN 1 366 600
The role of eGMP-dependent cellular signalling pathway in regulation of the expression and activity of SIRT1 deacetylase: a novel mechanism for the induction of insulin resistance in podocytes exposed to high glucose levels.
Project manager: Dorota Rogacka MD PhD
OPUS 12, implementation period: 2017 – 2021, project funding: PLN 1 102 805
The role of glutamine synthesis in the initiation phase of temporal epilepsy in a lithium-polycarpine model in juvenile rats: the mechanism of glutamine synthetase stimulation.
Project manager: Prof. Jan Albrecht MD PhD
OPUS 12, implementation period: 2017 – 2022, project funding: PLN 1 089 200
Pathomechanism of Charcot-Marie-Tooth disease type 4A– in the search of a therapy
Project manager: Prof. Andrzej Kochański MD PhD
OPUS 12, implementation period: 2017 – 2021, project funding: PLN 1 448 700
Role of the HSP90 chaperones in human adenovirus replication 5.
Project manager: Paweł Bieganowski MD PhD
OPUS 12, implementation period: 2017 – 2021, project funding: PLN 677 560
Design and evaluation of the multigene transcriptional signature for the purpose of molecular diagnostics of brain tumours in children.
Project manager: Anna Maria Łastowska MD PhD representing MMRI PAS (Leader: Institute of Monument Children's Health Centre)
OPUS 11, implementation period: 2017 – 2021, project funding: PLN 1 183 900
Blood-brain barrier damage in hepatic encephalopathy: the role of microRNA.
Project manager: Magdalena Zielińska MD PhD
OPUS 10, implementation period: 2016 – 2022, project funding: PLN 1 092 280
Ultrasonic vocalization - associated changes in circulatory parameters in rats.
Project manager: Robert Jakub Filipkowski MD PhD
OPUS 10, implementation period: 2016 – 2021, project funding: PLN 532 000
HARMONIA call for research projects:
The analysis of the mechanisms of hypotensive action of the stable 14,15-epoxyeicosatrienoic acid (EET-A) analogue
Project manager: Prof. Elżbieta Kompanowska-Jezierska
Project partner: Institute of Clinical and Experimental Medicine
International collaboration: The Czech Republic
HARMONIA 9, implementation period: 2018 – 2022, project funding: PLN 1 200 000
SONATA call for research projects:
The analysis of the biological role of PD-L1 for precise target adoptive anti-cancer therapies
Project manager: Agnieszka Graczyk-Jarzynka MD PhD
Project partner: Vrije University Medical Centre, Amsterdam; Oslo University Hospital
International collaboration: The Netherlands, Norway
SONATA 15, implementation period: 2020 – 2023, project funding: PLN 1 624 380
Neuregulin-1 overexpression in glial progenitors (GRPs) as a method of increasing the functional properties of GRPs.
Project manager: Luiza Stanaszek MD PhD
SONATA 13, implementation period: 2018 – 2022, project funding: PLN 598 600
The impact of prenatal activation of the immune system on mitochondrial functions. Implications for neurodevelopmental diseases.
Project manager: Magdalena Cieślik MD PhD
SONATA 12, implementation period: 2017 – 2021, project funding: PLN 559 800
The role of mitophagy and the assessment of changes in podocyte bioenergy in the development of insulin resistance and dysfunction of the filtration barrier in the pathogenesis of diabetic nephropathy
Project manager: Irena Audzeyenka MD PhD
SONATA 12, implementation period: 2017 – 2022, project funding: PLN 988 100
The role of mitofusin 2 in cell damage and regeneration in cerebral ischemic-reperfusion episode
Project manager: Małgorzata Kawalec MD PhD
SONATA 12, implementation period: 2017 – 2022, project funding: PLN 663 000
The design of NK1 receptor homologous model with the use of data on interspecies differences in ligand binding.
Project manager: Piotr Lipiński MD PhD
SONATA 12, implementation period: 2017 – 2021, project funding: PLN 499 850
SONATA BIS call for research projects:
The role of arginase 2 in the striatum functioning and in the pathogenesis of Huntington's disease.
Project manager: Michał Węgrzynowicz MD PhD
Sonata Bis 8, implementation period: 2019 – 2024, Project funding: 2 952 230 zł
STIM proteins as novel regulators of NMDA receptor transport in neurons.
Project manager: Joanna Gruszczyńska-Biegała MD PhD
Sonata Bis 7, implementation period: 2018 – 2023, project funding: PLN 1 999 191
Multi-onco-map: mapping the functions of leading oncogenes in human neoplastic diseases by multi-omics methods.
Project manager: Dawid Walerych MD PhD
Sonata Bis 7, implementation period: 2018 – 2022, project funding: PLN 1 992 400
SONATINA call for research projects:
The role of Tmbim5 protein in mitochondrial calcium homeostasis in zebrafish
Project manager: Iga Wasilewska MD PhD
Project partner: University Medical Center Mainz, Institute for Molecular Medicine
International collaboration: Germany
SONATINA 5, implementation period: 2021 – 2024, project funding: PLN 653 504
PRELUDIUM call for research projects:
A novel role for the peroxisome proliferator-activated alpha receptor in the regulation of amyloid beta peptide metabolism and mitochondrial function in an animal model of Alzheimer's disease.
Project manager: Sylwia Wójtowicz MA
PRELUDIUM 18, implementation period: 2020 – 2024, project funding: PLN 209 760
Molecular evaluation of neuroprotective and regenerative properties of WJ-MSC after transplantation into injured rat brain.
Project manager: Wioletta Lech MA
PRELUDIUM 18, implementation period: 2020 – 2022, project funding: PLN 140 000
The search for neuroprotective grounds of the activity of a specific NPY Y2 agonist (NPY13-36,) in a model of transient focal cerebral ischemia in rats.
Project manager: Łukasz Przykaza MA
PRELUDIUM 17, implementation period: 2020 – 2022, project funding: PLN 139 792
The activity and importance of bypass pathways of glucose glycolytic metabolism in response to changing aerobic conditions in long-term AD-MSC cell cultures.
Project manager: Anna Figiel-Dąbrowska MD PhD
PRELUDIUM 16, implementation period: 2019 – 2023, project funding: PLN 196 680
Hypoxia-induced factors and oligodendrocyte maturation disorders in the in vitro model of neonatal asphyxia.
Project manager: Justyna Janowska MA
PRELUDIUM 16, implementation period: 2019 – 2022, project funding: PLN: 210 000
The role of the signalling pathway mediated by sphingosine kinase / sphingosine-1-phosphate in the brains of mice with type II diabetes and following a high-fat diet. Search for potential neuroprotective effects of fingolimod and metformin.
Project manager: Przemysław Wencel PhD Eng.
PRELUDIUM 15, implementation period: 2019 – 2022, project funding: PLN 209 940
The role of lisosomes in insulin-dependent regulation of AMP-activated protein kinase expression and activity in podocytes. Influence on the permeability of the filtration barrier.
Project manager: Patrycja Rachubik MD PhD
PRELUDIUM 15, implementation period: 2019 – 2022, project funding: PLN 139 500
The role of NMDA receptors in the regulation of glutamine synthetase in cultured murine astrocytes. Defining intra-astrocytes signalling pathways.
Project manager: Katarzyna Skowrońska MD PhD
PRELUDIUM 14, implementation period: 2018 – 2022, project funding: PLN 140 000
The PRELUDIUM BIS call for research projects:
Identification of CD19-negative tumours surface proteins as an alternative traget in CAR-T cell therapy.
Project manager: Maria Winiarska MD PhD
PRELUDIUM BIS 2, implementation period: 2021 – 2025, project funding: PLN 532 800
The ETIUDA call for research projects:
The role of changes to the functioning of oligodendrocytes in pathogenesisi of white matter abnormalities following birth asphyxia.
Project manager: Justyna Janowska MA
ETIUDA 8, implementation period: 2020 – 2021, project funding: PLN 150 264
The MINIATURA call for research projects:
The role of adipocytokines in postprandila thermogenesis in people with normal and excess body mass.
Project manager: Agnieszka Kozacz MD PhD
MINIATURA 4, implementation period: 2021 – 2022, project funding: PLN 46 735
New combinations of HSP70 chaperone and proteasome inhibitors in inhibiting the growth of colon, pancreatic and lung cancer xenografts - an in vivo pilot study.
Project manager: Magdalena Oroń MD PhD
MINIATURA 4, implementation period: 2020 – 2021, project funding: PLN 49 680
Selected polyphenols as potential senolytic drugs modulating the senescence-associated secretory phenotype (SASP) in human keratinocytes.
Project manager: Anna Domaszewska-Szostek MD PhD
MINIATURA 4, implementation period: 2020 – 2021, project funding: PLN 49 500
Generation of induced pluripotent stem cells (iPSC) from patients with Dravet syndrome to model neuronal plasticity in genetically determined epilepsy in children.
Project manager: Valery Zayat MD PhD
MINIATURA 3, implementation period: 2020 – 2021, project funding: PLN 50 000
Development of a cell model derived from TP53 knockout rat neoplastic tissues.
Project manager: Kamil Synoradzki MD PhD
MINIATURA 4, implementation period: 2020 – 2021, project funding: PLN 49 995
The impact of exercise on the level of the CDNF / MANF family neurotrophic factors in a murine model of Parkinson's disease induced by intracerebral administration of alpha-synuclein oligomers.
Project manager: Ewelina Pałasz MD PhD
MINIATURA 4, implementation period: 2022 – 2023, project funding: PLN 49 852
Assessment of the role of astrocytes in tau-dependent neurodegeneration in an in vitro model of tau pathology
Project manager: Marta Sidoryk-Węgrzynowicz MD PhD
MINIATURA 4, implementation period: 2020 – 2021, project funding: PLN 49 698
The yeast model of diseases associated with the IGHMBP2 gene mutations.
Project manager: Weronika Rzepnikowska MD PhD
MINIATURA 4, implementation period: 2020 – 2021, project funding: PLN 21 560
The analysis of the interactions of mesenchymal stem cells and neoplastic stem cells of glioblastoma multiforme.
Project manager: Anna Andrzejewska MD PhD
MINIATURA 4, implementation period: 2020 – 2022, project funding: PLN 49 214
