The Centre of New Technologies, University of Warsaw invites to a seminar by
Prof. dr hab. Artur Osyczka
Department of Molecular Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
Title: Spectroscopic insights into molecular operation of cytochrome complexes of photosynthetic and respiratory systems
Date: 7th of December 2023, Thursday
Time: 1:00-2:00 pm (CET)
Host: Prof. Joanna Kargul
The seminar will be held in the main CeNT lecture hall (00.142) on the ground floor.
Abstract:
Energy-converting systems of photosynthesis and respiration couple electron and proton transfers to generate protonmotive force that powers cellular metabolism. These systems are composed of the enzymatic complexes embedding metal centers that enable specific electron and proton transfer reactions. In our research we explore molecular mechanisms of operation of such metalloproteins using various spectroscopic methods, in particular optical and electron paramagnetic resonance spectroscopy. Our particular focus is on enzymes that use quinols as substrates. They are ubiquitous, as quinone is of the most universal chemical compound present in membranes. They functionally link the enzymatic complexes and engage in redox reactions contributing to generation of protonmotive force. I will reflect on recent advances in understanding of molecular operation of three representatives of quinol oxidoreducatses that are being investigated in our laboratory: cytochrome bc 1 (mitochondrial complex III) that is part of respiratory chain (or photosynthetic chain in some bacteria), its photosynthetic counterpart – cytochrome b 6 f, and alternative complex III (ACIII) present in some bacterial chains. First two protein complexes belong to the family of cytochromes bc and are presumed to operate according to the same catalytic mechanism, although they feature intriguing structural differences of yet undefined function. ACIII is structurally unrelated to cytochromes bc and its mechanism is entirely unknown. I will discuss some aspects of inter-monomer electron transfer in dimeric cytochromes bc, mechanisms of oxidation of quinol and reduction of quinone -the two opposing redox reactions that are part of the catalytic cycle of these complexes, and mechanism of reactive oxygen species generation. I will also discuss the emerging new differences between cytochrome bc 1 and cytochrome b 6 f. I will show the progress in functional studies on ACIII that become possible due to the development of the first system for genetic manipulations of this complex.
Centrum Nowych Technologii Uniwersytet Warszawski
Centre of New Technologies University of Warsaw
tel. +48 (22) 55 43600
The Centre of New Technologies, University of Warsaw invites to a seminar by
Prof. Bartosz Różycki
Title: Conformational ensemble of the full-length SARS-CoV-2 nucleocapsid protein based on molecular simulations and SAXS data
Date: 24th of November 2023, Friday
Time: 12:00 pm (Central European Time)
Host: Silvio Osella, PhD
The seminar will be in the CeNT aula hall (00.142) on the main floor.
Abstract:
The nucleocapsid protein of the SARS-CoV-2 virus comprises two RNA-binding domains and three regions that are intrinsically disordered. While the structures of the RNA-binding domains have been solved using protein crystallography and NMR, current knowledge of the conformations of the full-length nucleocapsid protein is rather limited. To fill in this knowledge gap, we combined coarse-grained molecular simulations with data from small-angle X-ray scattering (SAXS) experiments using the ensemble refinement of SAXS (EROS) method. Our results show that the dimer of the full-length nucleocapsid protein exhibits large conformational fluctuations with its radius of gyration ranging from about 4 to 8 nm. The RNA-binding domains do not make direct contacts. The disordered region that links these two domains comprises a hydrophobic alpha-helix which makes frequent and nonspecific contacts with the RNA-binding domains. Each of the intrinsically disordered regions adopts conformations that are locally compact, yet on average, much more extended than Gaussian chains of equivalent lengths. We offer a detailed picture of the conformational ensemble of the nucleocapsid protein dimer under near-physiological conditions, which will be important for understanding the nucleocapsid assembly process.
Centrum Nowych Technologii Uniwersytet Warszawski
Centre of New Technologies University of Warsaw
tel. +48 (22) 55 43600
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Dear Sir / Madam,
We would like to invite you to submit a symposium proposal for NEURONUS 2024 Neuroscience Forum, which takes place between 25-27 April 2024 in Krakow, Poland.
CALL FOR SYMPOSIA for NEURONUS 2024 Neuroscience Forum is now OPEN!We await your proposals until 30th November 2023. More information can be found here: https://neuronusforum.pl/page/40,call-for-symposia
With prominent speakers and an unique atmosphere of one of the oldest and most beautiful Polish cities, NEURONUS Neuroscience Forums have established themselves in the European calendar of scientific events as a platform for communication between scientists from different fields of neuroscience.
The program of the conference consists of numerous sessions on biological, cognitive, computational and medical aspects of neuroscience, creating a dynamic environment for sharing knowledge. The schedule of the meeting is further complemented with lectures by invited guests, and we invest a lot of effort to attract as influential neuroscientists as possible. This year we will host 6 keynote speakers, among them Quentin Huys (University College London, UK), Sebastian Heasler (KU Leuven, Belgium) and James V. Haxby (Darthmout College, USA). More names revealed soon.
For example, in 2022 our keynote speakers were Lauri Nummenmaa (Turku PET Centre, Finland), Florian Engert (Harvard University, USA), Marina Bedny (Johns Hopkins University, USA), Mathias V. Schmidt (Max Planck Institute of Psychiatry, Germany), Suzana Herculano-Houzel (Vanderbilt University, USA), Charles Hillman (Northeastern University, USA), Valery Grinevich (University of Heidelberg, Germany).
During the upcoming 13th edition of the conference, we will continue to put emphasis on development of early-career researchers. The main purpose of this event is to provide means for both young and experienced neuroscientists to share the latest discoveries, knowledge and experience in neuroscience, as well as make valuable contacts with scientists representing various fields of neurobiology. We actively promote young scientists through preferentially allocating oral presentations of their experimental results. To help us achieve this goal, we have opened the call for symposia.
A symposium should last approximately 90 minutes, and be composed of talk by the Invited Speaker (of post-doc status or higher) and 3-4 talks given by early-career researchers. Early-career speakers may be proposed by the Symposium Organizer. At least two of early-career speakers must be at pre-doctoral level. The general focus of the symposium should fall within the scope of biological and cognitive neuroscience.
Please contact us at if more information is needed.We would sincerely appreciate your support in printing and displaying information about the call for symposia in your laboratories. Your cooperation in promoting this event would be invaluable. Thank you in advance for your assistance.
We strongly encourage you to join this special initiative and hope to see you in the beautiful scenery of Krakow!
Yours faithfully,Monika ŻuwałaOrganizing CommitteeNeuronus 2024 Neuroscience Forum
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Szanowni Państwo,
serdecznie zapraszam do udziału w warsztatach bioinformatycznych on-line dedykowanych naukowcom i prowadzonych przez naukowców. Nasze kursy uwzględniają elementy analizy statystycznej i wizualizacji stosowanych w publikacjach naukowych. Szkolenia mają charakter prowadzonych na żywo warsztatów ze sprawdzaniem postępów uczestników i możliwością zadawania pytań. Natomiast harmonogram regularnych najbliższych 2-dniowych warsztatów przedstawia się następująco:
Zaawansowana analiza danych metabolomicznych - 7.11.2023, 10.11.2023Analiza danych RNA-seq w R - 17-18.11.2023Analiza danych proteomicznych - 23-24.11.2023Wprowadzenie do R i RStudio - 6.12.2023, 8.12.2023Uczenie maszynowe w R od podstaw - 12-13.12.2023Analiza danych metabolomicznych - 5-6.02.2024Statystyka w R i RStudio - 14.02.2024, 16.02.2024Wstęp do programowania sztucznej inteligencji w Pythonie - 17-18.02.2024Uczenie głębokie w R (sieci neuronowe) - 19-20.02.2024Wprowadzenie do programowania - 22-23.02.2024Programowanie w Javie dla początkujących - 29.02-01.03.
Aby uzyskać więcej informacji o naszych szkoleniach oraz w celu rejestracji, zapraszamy do odwiedzenia naszej strony internetowej:https://xenstats.pl/warsztaty-
Serdecznie zapraszam również do udziału w nowych warsztatach w obszarze sztucznej inteligencji: „PROGRAMOWANIE I ZARZĄDZANIE SZTUCZNĄ INTELIGENCJĄ" dla grup zorganizowanych, który jest 60-godzinnym kursem 6-cio modułowym na temat sztucznej inteligencji. Więcej informacji o naszym nowym szkoleniu znajdą Państwo na stronie:
Ponadto, oferujemy również kursy stacjonarne dla zorganizowanych grup oraz specjalistyczne usługi bioinformatyczne i statystyczne w ramach projektów naukowych.
