Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw
is seeking a candidate
for a position of Post-doctoral Research Assistant
or Post-doctoral Research Associate*
* dependent on candidate’s qualifications
Recruitment is related to the project “The mechanisms of mitochondrial damage-dependent neuroinflammation in experimental models of Parkinson’s disease. The role of Parkin dysfunction” OPUS LAP no. 2020/39/I/NZ4/01031 funded by National Science Centre, Poland, carried out in the Department of Cellular Signaling MMRI PAS.
• Scientific discipline: medical sciences
• Announcement date: 19th November 2024
• Application deadline: 15th December 2024
• Link to the website: www.imdik.pan.pl
• Keywords: post-doc, Parkinson’s disease, neurodegeneration, α-synuclein, parkin, mitochondria damage, neuroinflammation.
The area of the research in which the candidate would participate:
Parkin and alpha-synuclein (α-syn) are two key proteins involved in the pathophysiology of Parkinson's disease (PD). This project will characterize the mechanisms by which α-syn–induced parkin dysfunction modulates mitochondrial damage and associated immune response in a pre-clinical murine model of PD based on bilateral injection of oligomeric α-syn into the striatum of C57BL/6J, parkin knock-out (Park2-/-) and parkin overexpressing (PARK2oe) mice. We are seeking a postdoctoral researcher for the project aimed to investigate parkin’s involvement in α-syn–evoked mitochondrial damage, inflammatory response, and neurodegeneration in our murine PD models. Candidate will be involved in investigation of:
1) the time-dependent impact of α-synuclein administration on inflammatory responses and parkin function;
2) the role of parkin in regulating the brain inflammatory response and neurodegeneration after intrastriatal administration of α-synuclein;
3) the effect of parkin overexpression in neuroanatomical and morphological changes evoked by α-synuclein;
4) the effects of pharmacological modulation of mitoflammation on neurodegeneration and behavioral disturbances caused by α-synuclein administration;
Addressing the role of parkin at the crossroads of α-syn spreading and neuroinflammation holds the promise for better understanding of PD pathomechanism and identification of novel therapeutic targets.
Description of duties:
• planning and implementation of research tasks in accordance with the schedule of the project,
• designing and conducting experiments with the use of biochemistry, molecular biology and microscopic imaging methods,
• analysis of obtained data,
• presenting the results at the group meetings, external seminars and scientific conferences,
• preparation of scientific publications,
• introducing new research technologies and cooperation with a foreign partner involved in the current research project.
Necessary Requirements:
• PhD degree in biological sciences, neurosciences, pharmacological sciences, medical sciences or relevant,
• experience in laboratory techniques in biochemistry, molecular biology (e.g. DNA, RNA, isolation; Western blot; qPCR; immunohistochemistry; spectrophotometric/fluorometric techniques),
• experience in planning and conducting in vivo procedures (e.g. behavioral analysis),
• working knowledge of statistical software (e.g. GraphPad Prism),
• ability to work in a team and independently,
• excellent knowledge of English, allowing effective communication and preparation of scientific manuscripts,
• indication of Mossakowski Medical Research Institute Polish Academy of Sciences as a first place of employment.
We offer:
• fixed term, full-time employment contract,
• contract period: January 2025 – November 2025,
• the opportunity to work in a pleased atmosphere, in a dynamic, developmental research group,
• scientific collaboration with a research partner in Germany and with other Polish and foreign research institutions,
• opportunity to participate and present obtained results at international conferences.
How to Apply:
Please send your documents to Ten adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript. indicating the reference number ZKTS-110-1/2024 in your correspondence.
Required documents:
• motivation letter with description of candidate’s scientific interests, scientific work, scientific independency, participation in research grants,
• CV listing candidate’s education, professional experience, scientific achievements, authored or co-authored publications and conference abstracts, internships and training,
• copy of the PhD (or equivalent) diploma,
• references (optionally).
* Depending on candidate’s qualifications, Recruitment Committee may recommend hiring a successful candidate as a Research Assistant or Research Associate.
For more information about the project, please contact prof. dr hab. Agata Adamczyk (Ten adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript.)
Expected date of the interview: 19th December 2024
Expected decision date: 20th December 2024
Expected job starting date: January 2025
INFORMATION CLAUSE ON PERSONAL DATA PROCESSING
Pursuant to Article 13 of Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation), Mossakowski Medical Research Institute, Polish Academy of Sciences hereby informs:
1. The Controller of your personal data is the Mossakowski Medical Research Institute, Polish Academy of Sciences, A. Pawińskiego 5 St., 02-106 Warsaw, Poland (“MMRI PAS”)
2. The Controller has designated the Data Protection Officer who can be contacted via the following e-mail address: Ten adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript. or the post address of Controller.
3. Your personal data will be processed for the purpose of carrying out a recruitment process and selecting an employee and concluding a contract for employment at the MMRI PAS.
4. MMRI PAS processes Your personal data in relation to a legal obligation (the Article 6.1.c of the GDPR) pursuant to Article 221 § 1 of the Act of 26 June 1974 Labour Code or Your consent understood by sending them to MMRI PAS (the Article 6.1.a of the GDPR) for data not listed on Labour Code, and their application does not affect the possibility of participating in the recruitment / competition. If you do not want us to process additional data, please do not include it in the documents.
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