Job Vacancy is announced
by the Director of Mossakowski Medical Research Institute, Polish Academy of Sciences
for the position of
assistant or assistant professor*
in the Laboratory of Molecular Basis of Neurodegeneration
City: Warsaw
Position: assistant or assistant professor
Scientific discipline: medical sciences
Announcement date: July 23rd, 2025
Application deadline: August 7th, 2025
Expected date of competition results announcement: the second half of August 2025
Date of taking the position: September, 2025
Link to Laboratory's website: Laboratory of Molecular Basis of Neurodegeneration
Keywords: neuropathology, neurodegeneration, Huntington’s disease, Parkinson’s disease, excitotoxicity, mouse models, acute slices, organotypic slices, striatum, hippocampus, arginine, polyamines, proteinopathy, biomarkers,
RT-QuIC.
* According to the assessment of candidate qualification the Commission may recommend her/his employment in an assistant
or assistant professor position.
The current research program of the Laboratory of Molecular Basis of Neurodegeneration:
• cellular and molecular mechanisms responsible for the pathogenesis of central nervous system disorders (Huntington’s disease, Parkinson’s disease, ischemic stroke);
• molecular basis of differential sensitivity of individual neuronal populations to defined neurotoxic factors;
• arginine metabolism in the pathology of the striatum and hippocampus;
• unique properties of hippocampal region CA2;
• the role of polyamines in regulating mitochondrial calcium flux in the hippocampus;
• searching for novel biomarkers in neurodegenerative diseases;
• the use of amyloid protein amplification-based methods for the search for new drugs against neurodegenerative diseases.
The area of the research in which the candidate would participate:
• changes in arginase 2 activity, expression, and distribution and in arginine metabolism in the mouse model
of Huntington’s disease;
• behavioral and neuropathological studies of a mouse model of Huntington’s disease under arginase 2 deficiency;
• studying changes in polyamine distribution in the hippocampus under excitotoxicity and hypoxia using bioorthogonal probes and click chemistry;
• optimization and application of the RT-QuIC method for the identification of early biomarkers of neurodegeneration and for the search for new pharmacological agents in the treatment of tauopathies and synucleinopathies.
Description of job position activities:
• generating experimental models and collecting biological material;
• conducting in vivo studies;
• performing chemical, biochemical, histological, and microscopic experiments;
• implementing new research technologies to improve the quality of scientific studies;
• active participation in the scientific activities of the Laboratory, the Institute, and the scientific community;
• active acquisition of research funding by preparation of grant applications in accordance with competition rules;
• active participation in the implementation of research projects, following the requirements of the financing institution;
• preparing reports on conducted research;
• analysis and presentation of the obtained data;
• preparation of manuscripts and their publication;
• preparation of conference presentations, and representing the Institute at scientific conferences;
• active participation in seminars, courses, and trainings.
Requirements for the position of assistant:
• having a master's degree (or equivalent) in the field of medical, biological or related sciences;
• experience in molecular biology, biochemistry, histology, and microscopy techniques (e.g. PCR, qPCR, western blotting, fluorimetric/spectrophotometric assays, enzymatic assays, enzyme activity assays, histological/immunohistochemical tissue staining, brightfield microscopy, confocal microscopy);
• experience in working with rodents (supported with appropriate certifications);
• experience in tissue cultures;
• independence and good organizational skills;
• creativity and ability to work in a team;
• indication of Mossakowski Medical Research Institute, Polish Academy of Sciences as the first place of employment;
• fluency in English.
Additional requirements (desirable) for the position of assistant:
• experience with animal models of neurodegenerative diseases;
• practical knowledge of mouse and/or rat brain anatomy;
• ability to analyze and present acquired results;
• knowledge of statistical methods used in scientific research;
• experience in preparing grant proposals;
• documented participation in scientific conferences;
• authorship/co-authorship of scientific publications;
• ability to design, organize, and conduct scientific research and to propose research hypotheses.
Requirements for the position of the assistant professor:
• at least a Ph.D. degree in medical, biological, or related sciences;
• having at least 2 original scientific publications in scientific journals indexed in JCR including at least one of which the candidate is the first, equivalent, or corresponding author, published after the doctorate, but not containing the results of the doctorate;
• experience in molecular biology and biochemistry techniques (e.g. PCR, qPCR, western blotting, fluorometric and spectrophotometric assays, enzyme-based assays, enzyme activity measurements, sample preparation for chromatographic and mass spectrometry analyses);
• experience in histological and microscopy techniques (histological/immunohistochemical tissue staining, brightfield microscopy, confocal microscopy);
• experience in working with rodents, with appropriate certification;
• experience in maintaining and working with tissue cultures;
• practical knowledge of mouse and/or rat brain anatomy;
• ability to design, organize, and conduct scientific research and to propose research hypotheses;
• ability to analyze and present acquired results, including large-scale data sets;
• experience in preparing grant proposals;
• strong independence and excellent organizational skills;
• creativity and ability to work in a team;
• knowledge of statistical methods used in scientific research;
• indication of Mossakowski Medical Research Institute, Polish Academy of Sciences as the first place of employment;
• documented active participation in international conferences and symposia;
• fluency in English.
Additional requirements (desirable) for the position of assistant professor:
• experience in working with animal models of neurodegenerative diseases;
• practical knowledge of live imaging microscopy techniques;
• experience in working with acute slices;
• practical knowledge of techniques for identifying amyloid proteins;
• practical knowledge of methods used in neuropathological analyses.
We offer:
• employment contract (full-time position);
• opportunity for scientific development and independence in project management for which funding was obtained independently by the candidate;
• participation in the implementation of other projects;
• opportunity to attend conferences and to participate in internships abroad;
• additional support from the social fund;
• opportunity to join a group insurance program, medical service package, and to obtain a Multisport card on preferential terms;
• work in a good team, in a nice atmosphere.
Required documents:
• cover letter with information about scientific interests;
• curriculum vitae containing information on education, scientific achievements, and previous jobs;
• list of publications, in the case of an assistant professor with the indication of papers published before the doctorate, and papers published after the doctorate;
• a copy of the diploma confirming the possession of the required professional title or academic degree;
• documents confirming the fulfillment of other requirements specified in the announcement of the competition.
How to apply:
The application should be addressed to the Director of Mossakowski Medical Research Institute, Polish Academy
of Sciences. The required documents in electronic form (pdf format only) should be sent to the following e-mail address: Ten adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript. and must be received by the Institute by August 7th, 2025.
Please include the following job offer identification number in your application: SDI.111.4.2025.
The date of receipt of documents by IMDiK PAN is decisive - the applications received after the deadline will not be considered.
Anticipated result announcement date: the second half of August 2025
Envisaged job starting date: September 2025
The competition for the post of assistant or assistant professor is carried out following "Regulations of the employment for the scientific positions in MMRI PAS".
INFORMATION CLAUSE ON PERSONAL DATA PROCESSING
According to Article 13 of Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons concerning the processing of personal data and the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation), Mossakowski Medical Research Institute, Polish Academy of Sciences hereby informs:
1. The Controller of your data is the Mossakowski Medical Research Institute, Polish Academy of Sciences, A. Pawińskiego 5 St., 02-106 Warsaw, Poland ("MMRI PAS")
2. The Controller has designated the Data Protection Officer who can be contacted via the following e-mail address: Ten adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript. or the postal address of the Controller.
3. Your data will be processed to carry out a recruitment process and select an employee and conclude a contract for employment at the MMRI PAS.
4. MMRI PAS processes Your data concerning a legal obligation (Article 6.1.c of the GDPR) according to Article 221 § 1 of the Act of 26 June 1974 Labour Code or Your consent understood by sending them to MMRI PAS (Article 6.1.a of the GDPR) for data not listed on Labour Code, and their application does not affect the possibility of participating in the recruitment/competition. If you do not want us to process additional data, please do not include it in the documents.
5. By submitting your candidacy, you consent to the fact that if you win the recruitment/competition, your name and surname together with information about the recommendation for employment will be posted on the MMRI PAS website.
6. Your application with personal data will be processed for the period necessary for the realization of purposes indicated in p. 3 - for a maximum of one month and then your application with personal data will be deleted.
7. Concerning the processing of Your data for purposes mentioned in p. 3, Your data might be shared with the following recipients or categories of recipients: entities supporting MMRI PAS in its business processes, in particular administrative and economic service and authorized entities.
8. Within the limits and on the terms set out in the GDPR, you have the right to request access to your data, rectification, deletion, or limitation of processing, as well as the right to submit a declaration of withdrawal of consent to the processing of personal data at any time. Withdrawal of consent does not affect the lawfulness of the processing which was carried out based on consent before its withdrawal, as well as the processing of data processed by the administrator based on other provisions.
9. You have the right to lodge a complaint to the President of the Office for the Protection of Personal Data (ul. Stawki 2, 00-193 Warszawa).
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